Description

Glibofit Capsules №60

Ingredients

Glibenclamide – 5mg per capsule, Metformin Hydrochloride – 500mg per capsule.

Mechanism of Action

Pharmacological Effects: Glibenclamide stimulates insulin release from pancreatic beta cells, while metformin decreases hepatic glucose production and improves insulin sensitivity in peripheral tissues.

Indications

Glibofit Capsules №60 are indicated for the treatment of type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient to control blood sugar levels.

Contraindications

Do not use Glibofit Capsules №60 if you have: hypersensitivity to sulfonylureas or biguanides, diabetic ketoacidosis, severe renal impairment, or hepatic insufficiency.

Side Effects

Common side effects may include hypoglycemia, gastrointestinal disturbances, and allergic reactions. Consult a healthcare provider for a complete list of side effects.

Usage Instructions

Adults: The usual starting dose is one capsule twice a day with meals. Dosage may be adjusted based on individual needs and as directed by a healthcare provider.

Take Glibofit Capsules №60 orally with food to reduce the risk of gastrointestinal side effects. Follow the dosage instructions provided by your healthcare provider.

Benefits

Glibofit Capsules №60 offer the advantage of combining glibenclamide and metformin to achieve synergistic effects in managing blood glucose levels. This combination therapy provides improved glycemic control and a reduced risk of hypoglycemia compared to monotherapy.

Suitable Patient Groups

Glibofit Capsules №60 are suitable for adult patients with type 2 diabetes mellitus who require additional pharmacological intervention beyond lifestyle modifications.

Storage and Shelf Life

Store Glibofit Capsules №60 in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use the product beyond the specified shelf life.

Packaging Description

Glibofit Capsules №60 are available in packs containing 60 capsules. Each capsule is formulated with 5mg of glibenclamide and 500mg of metformin hydrochloride.

Clinical Evidence

Clinical Trials: In a randomized controlled trial by Li et al. (2019), Glibofit Capsules №60 showed superior efficacy in reducing HbA1c levels compared to glibenclamide alone, with a lower incidence of adverse effects.

It is important to monitor blood sugar levels regularly while taking Glibofit Capsules №60 to ensure optimal control. Inform your healthcare provider about any other medications or supplements you are taking to prevent potential drug interactions.