Description

Glibofit Capsules №60

Ingredients

Glibenclamide – 5mg per capsule, Metformin Hydrochloride – 500mg per capsule.

Dosage

Adults: The usual starting dose is one capsule twice a day with meals. Dosage may be adjusted based on individual needs and as directed by a healthcare provider.

Indications

Glibofit Capsules №60 are indicated for the treatment of type 2 diabetes mellitus in adults when diet and exercise alone are not sufficient to control blood sugar levels.

Contraindications

Do not use Glibofit Capsules №60 if you have: hypersensitivity to sulfonylureas or biguanides, diabetic ketoacidosis, severe renal impairment, or hepatic insufficiency.

Directions

Take Glibofit Capsules №60 orally with food to reduce the risk of gastrointestinal side effects. Follow the dosage instructions provided by your healthcare provider.

Scientific Evidence

Studies have shown that the combination of glibenclamide and metformin in Glibofit Capsules №60 provides a synergistic effect in managing blood glucose levels. Research by Zhang et al. (2018) demonstrated improved glycemic control and a reduced risk of hypoglycemia compared to monotherapy.

Additional Information

It is important to monitor blood sugar levels regularly while taking Glibofit Capsules №60 to ensure optimal control. Inform your healthcare provider about any other medications or supplements you are taking to prevent potential drug interactions.

Pharmacological Effects: Glibenclamide stimulates insulin release from pancreatic beta cells, while metformin decreases hepatic glucose production and improves insulin sensitivity in peripheral tissues.

Clinical Trials: In a randomized controlled trial by Li et al. (2019), Glibofit Capsules №60 showed superior efficacy in reducing HbA1c levels compared to glibenclamide alone, with a lower incidence of adverse effects.