Description
Glibofor Coated Tablets 500 mg/5 mg. №60
Composition
Each coated tablet contains 500 mg of Glibenclamide and 5 mg of Metformin hydrochloride.
Mechanism of Action
Glibofor tablets stimulate insulin release from pancreatic beta cells (Glibenclamide) and reduce hepatic glucose production while improving insulin sensitivity (Metformin), leading to effective lowering of blood sugar levels.
Pharmacological Properties
Glibofor tablets combine the actions of Glibenclamide and Metformin to improve glycemic control in patients with type 2 diabetes.
Indications for Use
Glibofor tablets are indicated for the treatment of type 2 diabetes mellitus to help control blood sugar levels in patients unable to achieve sufficient glycemic control with diet and exercise alone.
Contraindications
Avoid using Glibofor tablets in patients with type 1 diabetes, diabetic ketoacidosis, severe renal impairment, or hypersensitivity to sulfonylureas or biguanides.
Side Effects
Common side effects may include hypoglycemia, gastrointestinal disturbances, and allergic reactions. Consult a healthcare provider for a full list of potential side effects.
Usage Instructions
The typical dosage is one tablet taken twice daily with meals. Dosage adjustments may be necessary based on individual medical conditions.
Benefits Compared to Analogues
Glibofor tablets offer the advantage of dual therapy with Glibenclamide and Metformin, resulting in improved glycemic control compared to monotherapy with either drug alone.
Suitable Patient Groups
Glibofor tablets are suitable for adult patients with type 2 diabetes. Dosage adjustments may be required for specific patient groups such as the elderly or individuals with renal impairment.
Storage and Shelf Life
Store Glibofor tablets in a cool, dry place away from direct sunlight. Check the packaging for the expiration date and do not use expired tablets.
Packaging Description
Glibofor tablets are packaged in blister packs containing 60 coated tablets.
Clinical Evidence and Proven Effectiveness
Glibofor tablets have been shown in studies to effectively reduce HbA1c levels and fasting plasma glucose when compared to monotherapy. Research by Kahn et al. demonstrated significant improvements in glycemic control with the Glibenclamide-Metformin combination.
Additional Information
Regular monitoring of blood glucose levels is essential while taking Glibofor tablets to ensure optimal dosage adjustments. Inform your healthcare provider about all medications you are using to prevent potential interactions. A healthy diet and exercise routine complement the treatment regimen for better outcomes.
