Glutargyn alcoclean tablets 1g. №10

Description

Glutargyn №10 Storage
active substance: arginine glutamate;

1 tablet contains 1 g of arginine glutamate;

excipients: microcrystalline cellulose, crospovidone, calcium stearate.

Glutargyn №10 Dosage form
Tablets.

Main physical and chemical properties: white tablets of elongated shape with a biconvex surface with a line.

Glutargyn №10 Pharmacotherapeutic group
Drugs used in liver disease, lipotropic substances. Hepatotropic drugs. Arginine glutamate. ATX code A05B A01.

Pharmacological properties

Pharmacodynamics.

Glutargin alkocline is a salt of arginine and glutamic acid.

In alcohol intoxication, the drug stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme utilization of ethanol – alcohol dehydrogenase; accelerates the inactivation and excretion of toxic products of ethanol metabolism as a result of increased formation and oxidation of succinic acid; reduces the depressant effect of alcohol on the central nervous system (CNS) due to the neurotransmitter properties of excitatory glutamic acid. Due to these properties, the drug has antitoxic and sobering effects.

The drug also has hepatoprotective and hypoammonemic properties. The hepatoprotective effect of the drug is due to its antioxidant, antihypoxic and membrane stabilizing properties, as well as a positive effect on the energy supply processes in hepatocytes. Hypoammonemic effects of the drug are realized by activating the neutralization of ammonia in the ornithine cycle of urea synthesis, binding of ammonia to non-toxic glutamine, as well as increasing the excretion of ammonia from the CNS and its excretion from the body. Due to these properties of the drug, the general toxic, including neurotoxic effects of ammonia are reduced.

In experimental animal studies, the drug did not show embryotoxic, gonadotoxic, mutagenic and teratogenic effects, did not cause allergic and immunotoxic reactions.

Pharmacokinetics.

Not investigated.

Indication
Prevention of intoxication and hepatotoxic effects of alcohol. Treatment of acute alcohol intoxication of mild and moderate severity, as well as part of the complex therapy of post-intoxication disorders after severe alcohol poisoning.

Contraindication
Hypersensitivity to the components of the drug. The state of fever, increased excitability, severe violation of the filtration (nitrogen) function of the kidneys.

Interaction with other medicinal products and other forms of interaction
The effect of the drug on insulin secretion is increased by concomitant use of aminophylline. The drug may increase the effect of antiplatelet drugs (dipyridamole). Prevents and alleviates neurotoxic effects that may occur with the use of isoniazid. Weakens the effect of vinblastine.