Glutargyn solution for injections 20% ampoules 5 ml. №10

Description

Glutargyn 20% Storage
active substance: arginine glutamate;

1 ml of solution contains arginine glutamate 200 mg;

Excipient: water for injections.

Glutargyn 20% Dosage form
Solution for injection.

Main physical and chemical properties: clear colorless or slightly yellowish solution.

Glutargyn 20% Pharmacotherapeutic group
Drugs used in liver disease, lipotropic drugs. Arginine glutamate. ATX code A05B A01.

Pharmacological properties

Pharmacodynamics.

Glutargin – a salt of arginine and glutamic acid, which play an important role in ensuring the biochemical processes of neutralization and excretion of a highly toxic metabolite of nitrogenous substances – ammonia. Hypoammonemic effects of the drug are realized by activating the neutralization of ammonia in the ornithine cycle of urea synthesis, binding of ammonia to non-toxic glutamine, as well as enhancing the excretion of ammonia from the central nervous system (CNS) and its excretion from the body. Due to these properties of the drug are reduced general toxicity

including neurotoxic, effects of ammonia.

Glutargin also has a hepatoprotective effect due to its antioxidant, antihypoxic and membrane stabilizing properties, has a positive effect on the energy supply processes in hepatocytes.

In alcohol intoxication, the drug stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for the utilization of ethanol – alcohol dehydrogenase; accelerates the inactivation and excretion of toxic products of ethanol metabolism due to increased formation and oxidation of succinic acid; reduces the depressant effect of alcohol on the CNS due to the neurotransmitter excitatory properties of glutamic acid. Due to these properties, the drug has antitoxic and sobering effects.

In pathology of pregnancy due to endothelial protective action, the drug reduces impaired vascular permeability and thromboresistance, prevents hypercoagulation, reduces vascular sensitivity to vasoconstrictors (endothelin, angiotensin, thromboxane), which cause generalized vasospasm. Arginine after preliminary biotransformation into nitric oxide has a vasodilating effect, has a positive effect on blood clotting and functional properties of circulating blood elements. As a result of vasodilatory and antihypoxic effects of the drug improves maternal and fetal hemodynamics, reduces fetal hypoxia. In pathology of pregnancy, the drug also exhibits antitoxic and hepatoprotective activity, acts as a non-specific metabolic regulator of metabolic processes. Due to these properties of the drug during pregnancy, the level of immune complexes circulating in the blood decreases, the severity of the syndrome of “metabolic” intoxication and immunotoxicosis decreases, compensatory-adaptive reactions of the body are activated.

Glutargin does not show embryotoxic, gonadotoxic, mutagenic and teratogenic effects, does not cause allergic and immunotoxic reactions.

Pharmacokinetics.

Not studied.

Indication
As part of the complex therapy of acute and chronic hepatitis of various etiologies, including poisoning with hepatotropic poisons (pale toadstool, chemicals and drugs), liver cirrhosis, leptospirosis, including conditions accompanied by hyperammonemia.

Hepatic encephalopathy, precoma and coma accompanied by hyperammonemia.

Acute alcohol poisoning of moderate and severe degree, including alcoholic encephalopathy and coma.

Complications in the III trimester of pregnancy: late preeclampsia, including its severe forms – preeclampsia and eclampsia, fetoplacental insufficiency, chronic pathologies of the hepatobiliary system in pregnant women, including conditions accompanied by hyperammonemia.

Contraindication
Hypersensitivity to the components of the drug. The state of fever, increased excitability and psychotic reactions with a violent course. Severe violation of the filtration (nitrogen) function of the kidneys.