Glutargyn solution for injections 4% 5 ml. №10

Description

GLUTARGYN 4% COMPOSITION
active substance: 1 ml of arginine glutamate 40 mg

excipients: water for injection.

GLUTARGYN 4% DOSAGE FORM
Injection.

GLUTARGYN 4% MAIN PHYSICAL AND CHEMICAL PROPERTIES
transparent colorless liquid.

PHARMACOLOGICAL GROUP
Drugs used for liver diseases, lipotropic substances. Hepatotropic drugs. Arginine glutamate. ATX code A05B A01.

PHARMACOLOGICAL PROPERTIES
Pharmacological. Glutargin is a combination of arginine and glutamic acid, which play an important role in the biochemical processes of neutralization and elimination from the body of a highly toxic metabolite of nitrogenous substances – ammonia. The hypoammonaemic effects of the drug are realized by activating the neutralization of ammonia in the ornithine cycle of urea synthesis, binding of ammonia to non-toxic glutamine, as well as enhancing the excretion of ammonia from the central nervous system and its excretion from the body. Thanks to these properties of the drug, the general toxic, including the neurotoxic effects of ammonia, are reduced.

Glutargin also has a hepatoprotective effect due to its antioxidant, antihypoxic and membrane stabilizing properties, and has a positive effect on the processes of energy supply in hepatocytes.

In case of alcohol intoxication, the drug stimulates the utilization of alcohol in the monooxygenase system of the liver, prevents the inhibition of the key enzyme for the utilization of ethanol – alcohol dehydrogenase, accelerates the inactivation and excretion of toxic products of ethanol metabolism as a result of an increase in the formation and oxidation of succinic acid, and reduces the inhibitory effect of alcohol on the central nervous system due to the neurotransmitter properties of excitatory acid. Due to these properties, the drug exhibits antitoxic and sobering effects.

Glutargin does not exhibit embryotoxic, gonadotoxic and mutagenic effects, does not cause allergic and immunotoxic reactions.

Pharmacokinetics. Has not been investigated.

INDICATIONS
In the complex therapy of acute and chronic hepatitis of various etiologies, incl. In case of poisoning with hepatotropic poisons (pale toadstool, chemical and medicinal substances), cirrhosis of the liver, leptospirosis, incl. Conditions accompanied by hyperammonemia.

Hepatic encephalopathy, coma and coma, accompanied by hyperammonemia.

The state of acute alcoholic poisoning of moderate and severe degree, including Alcoholic encephalopathy and coma. Post-intoxication disorders caused by alcohol use.

Complications in the third trimester of pregnancy: late gestosis, including its severe forms – preeclampsia and eclampsia, placental insufficiency, chronic pathologies of the digestive system in pregnant women, including conditions accompanied by hyperammonemia.

CONTRAINDICATIONS
Hypersensitivity to the components of the drug. A state of fever, increased excitability and psychotic reactions with a violent course, severe impairment of the filtration (nitrogen-excreting) function of the kidneys.