Glutargyn tablets 0.75 №10

Description

Glutargyn Composition
active substance: arginine glutamate.

1 tablet contains arginine glutamate 250 mg (0.25 g) or 750 mg (0.75 g);

excipients: dosage of 250 mg – microcrystalline cellulose, crospovidone, croscarmellose sodium, calcium stearate; dosing 750 mg – microcrystalline cellulose, crospovidone, calcium stearate.

Glutargyn Dosage form
Pills.

Basic physical and chemical properties: dosage of 250 mg – white tablets, with a flat surface, with a line and a chamfer; dosing 750 mg – tablets of white color, elongated shape with a chamfer, with a notch.

Glutargyn Pharmacological group
Drugs used for liver diseases, lipotropic substances. Hepatotropic drugs. Arginine glutamate. ATX code A05B A01.

Pharmacological properties

Pharmacodynamics

Glutargin is a salt of arginine and glutamic acid, which play an important role in providing biochemical processes of neutralization and excretion of a highly toxic metabolite of nitrogenous substances – ammonia from the body. The hypoammonaemic effects of the drug are realized by activating the neutralization of ammonia in the ornithine cycle of urea synthesis, binding of ammonia to non-toxic glutamine, as well as enhancing the excretion of ammonia from the central nervous system and its excretion from the body. Thanks to these properties of Glutargin, the general toxic, including the neurotoxic effects of ammonia, are reduced.

Glutargin also has a hepatoprotective effect due to antioxidant, antihypoxic and membrane stabilizing properties, and has a positive effect on the processes of energy supply in hepatocytes.

Pharmacokinetics

Has not been investigated.

Indications
As part of the complex therapy of acute and chronic hepatitis of various etiologies, including in case of poisoning with hepatotropic poisons (pale toadstool, chemical and medicinal substances), in liver cirrhosis, leptospirosis.
Hepatic encephalopathy accompanied by hyperammonemia.
Acute alcohol poisoning of mild and moderate severity, hangover syndrome, post-intoxication disorders caused by alcohol intake.
Complications in the third trimester of pregnancy: late gestosis, including its severe forms – preeclampsia and eclampsia, placental insufficiency, chronic pathologies of the digestive system in pregnant women.

Contraindications
Hypersensitivity to the components of the drug. Fever, hyperexcitability, severe impairment of the filtration (nitrogen-excreting) function of the kidneys.