Gordox solution for injections 100000 ampoules 10 ml. №25

Description

Gordox №25 Composition

active substance: aprotinin
1 ml 10000 CIUD of aprotinin
excipients: sodium chloride, benzyl alcohol, water for injection.

Gordox №25 Dosage form

Injection.

Gordox №25 Pharmacological group

Fibrinolysis inhibitors. Aprotinin.
ATC code B02A B01.

Indications

Aprotinin is indicated for prophylaxis in order to reduce postoperative blood loss and the need for blood transfusion in adult patients who have a high risk of large blood loss during isolated cardiopulmonary bypass grafting (i.e. coronary artery bypass grafting, not combined with other cardiovascular interventions).

Aprotinin should only be used after careful study of the benefits and risks, and note that alternative treatments are available.

Contraindications

Hypersensitivity to the active substance or to any of the excipients. Patients with IgG antibodies specific to aprotinin have an increased risk of anaphylaxis during treatment with aprotinin. In this regard, aprotinin therapy is contraindicated in such patients.

If testing for specific IgG antibodies against aprotinin before starting treatment is not possible, but it is assumed that the patient has received aprotinin treatment within the previous 12 months, the administration of aprotinin is contraindicated.

Method of administration and dosage

Except in cases where the nature of the appointments is different, the following dosages of the drug are recommended for adult patients:

Test dose

Due to the risk of developing an allergic (anaphylactic) reaction, all patients should be injected intravenously with 10,000 CIUD (kallikrein-inhibiting units) aprotinin (1 ml) at least 10 minutes before the initial dose. If the initial dose of 1 ml did not cause an allergic reaction, then a therapeutic dose can be administered.

Antagonists H 1 and H 2 can be administered 15 minutes before the test with Aprotinin. Equipment for routine emergency treatment of anaphylactic and allergic reactions should be available.

During open heart surgery (with a heart-lung machine) to reduce blood loss and the need for blood transfusion:

Dosage After entering anesthesia (but before performing a sternotomy), it is recommended to administer a loading dose of 1,000,000 to 2,000,000 KIED by slow injection or infusion over 20-30 minutes. The next 1,000,000-2,000,000 KIUD should be administered after the heart-lung machine is turned on. To avoid physical incompatibility between aprotinin and heparin that is added to the pump priming solution, each drug must be added to the pump priming solution during recirculation to ensure that these drugs are sufficiently diluted before they are mixed with each other. After the initial high dose bolus infusion, 250,000 to 500,000 CIUU per hour should be administered by continuous infusion until the end of the operation.