$9.10
Manufacturer: Ukraine/Spain
Local treatment of Trichomonas and non-specific vaginitis.
Description
Gravagyn Composition
active substance: metronidazole;
1 pessary contains metronidazole 500 mg;
Gravagyn excipients:
lipophilic base.
Gravagyn Dosage form
Pessaries.
Basic physical and chemical properties: pessaries of white color with a slightly yellowish or yellowish-greenish shade, ovoid (ovules).
Pharmacotherapeutic group
Antimicrobial and antiseptic agents used in gynecology. Imidazole derivatives. ATX code G01A F01.
Pharmacodynamics
Metronidazole is a derivative of 5-nitroimidazole, has a wide spectrum of antimicrobial action against gram-positive and gram-negative obligate anaerobic bacteria, as well as protozoa. Sensitive to the drug: Peptostreptococcus spp., Clostridium spp., Bacteroides spp., Fusobacterium spp., Porphyromonas, Bilophila, Helicobacter pylori, Prevotella spp., Veilonella. Metronidazole inhibits the development of protozoa Trichomonas vaginalis, Entamoeba histolytica, Giardia intestinalis (Lamblia intestinalis). Inconsistently sensitive to the drug: Bifidobacterium spp., Eubacterium spp. Sensitive to the drug: Propionibacterium, Actinomyces, Mobiluncus.
Pharmacokinetics
With intravaginal use, systemic absorption of metronidazole is minimal. The half-life of metronidazole that has entered the systemic circulation is 8-10 hours. Less than 20% of metronidazole binds to blood proteins. There is a rapid and pronounced diffusion into the lungs, kidneys, liver, bile, cerebrospinal fluid, skin, saliva and vaginal secretions. It crosses the placenta and is excreted in breast milk. It is metabolized in the liver to form two unconjugated oxidized active metabolites (5-30% activity). Excretion of the drug occurs mainly by the kidneys: 35-65% is excreted in the urine unchanged and in the form of metabolites.
Indications
Local treatment of Trichomonas and nonspecific vaginitis.
Contraindications
Hypersensitivity to metronidazole or other components of the drug. Hypersensitivity to imidazole derivatives. It is not recommended to prescribe the drug at the same time as disulfiram or alcohol (see Section “Interaction with other medicinal products and other types of interactions”).
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