Gripgo Chotmix granules for oral suspension 5 g. sachet №10

Description

Gripgo Chotmix Composition
active ingredients: paracetamol, phenylephrine hydrochloride, ascorbic acid;

1 sachet contains paracetamol 750 mg, phenylephrine hydrochloride 10 mg, coated ascorbic acid in terms of ascorbic acid 60 mg

excipients: sucrose, sodium saccharin, povidone, citric acid, sodium citrate, corn starch, ponceau 4R (E 124), strawberry flavor.

Gripgo Chotmix Dosage form
Granules for oral solution, strawberry flavor.

Basic physical and chemical properties: granular powder from light pink to pink with the inclusion of white granules of various shapes.

Gripgo Chotmix Pharmacotherapeutic group
Analgesics and antipyretics. Paracetamol, combinations without psycholeptics. ATX code N02B E51.

Pharmacodynamics
Gripgo Hotmix® is a combined drug, the action of which is due to the components that make up its composition.

Paracetamol is an analgesic-antipyretic that has antipyretic and analgesic properties, which is associated with the effect of paracetamol on the hypothalamic center of thermoregulation and its ability to inhibit the synthesis of prostaglandins.

Phenylephrine hydrochloride is a sympathomimetic agent that reduces swelling of the nasal mucosa and paranasal sinuses, the severity of exudative manifestations, improves nasal breathing. It stimulates mainly alpha-adrenergic receptors, due to which there is a narrowing of peripheral vessels and a decrease in their permeability, and the formation of mucous secretions decreases.

Ascorbic acid is a vital vitamin that is added to the drug to compensate for the loss of vitamin C that may occur at the beginning of a viral infection. Ascorbic acid is actively involved in the redox reactions of the body. It stimulates tissue respiration, oxidative phosphorylation in the liver, activates proteolytic and microsomal enzymes, promotes the transition of folic acid to folinic acid. Ascorbic acid is essential for the synthesis of steroid hormones and procollagen. It regulates the permeability of the walls of blood vessels, blood coagulability, promotes regeneration processes, and promotes the formation of supporting tissues. Ascorbic acid promotes the activation of the immune system, replenishes the increased need for vitamin C in case of flu and colds, strengthens the body’s defense mechanisms.

Pharmacokinetics
There are no corresponding pharmacokinetic data.

Indications
Short-term relief of symptoms of colds and flu, including headache, fever, nasal congestion, sinusitis and associated pain, sore throat, body aches.

Contraindications
Sensitivity to any component of the drug;
severe liver dysfunction, congenital hyperbilirubinemia, acute hepatitis, Gilbert’s syndrome;
blood diseases, deficiency of glucose-6-phosphate dehydrogenase, leukopenia, anemia, thrombosis, thrombophlebitis;
rare hereditary states of fructose intolerance, impaired absorption of glucose-galactose or sucrose-isomaltose insufficiency;
severe diseases of the cardiovascular system, including severe arterial hypertension, severe atherosclerosis, ischemic heart disease, decompensated heart failure; conduction disturbance tendency to vasospasm;
severe renal dysfunction, prostatic hypertrophy with difficulty urinating;
states of increased excitement, sleep disturbances, epilepsy;
hyperthyroidism, severe forms of diabetes mellitus, phenylketonuria;
acute pancreatitis;
glaucoma;
alcoholism;
age up to 12 years; elderly age;
During pregnancy and breastfeeding;
simultaneous reception with:
MAO inhibitors (MAO) and within 2 weeks after the withdrawal of MAO inhibitors;
tricyclic antidepressants;
β-blockers or other antihypertensive drugs;
drugs that suppress or increase appetite;
amphetopathic psychostimulants.