Gripomed capsules №20

$8.00

Manufacturer: Ukraine

Symptomatic treatment of colds accompanied by high body temperature, headache, swelling of the nasal mucosa (rhinitis).

Category:

Description

Gripomed capsules Composition
active ingredients: paracetamol, caffeine, chlorpheniramine maleate, ascorbic acid;

1 capsule contains: paracetamol – 200 mg, caffeine – 25 mg, chlorpheniramine maleate – 2.5 mg, ascorbic acid – 150 mg;

excipients: calcium stearate, talc, stearic acid, anhydrous colloidal silicon dioxide, povidone, potato starch, croscarmellose sodium.

Gripomed capsules Dosage form
Capsules.

Basic physical and chemical properties: hard gelatin capsules with a blue opaque lid and a white opaque body, containing a powder of white with a creamy shade of color.

Gripomed capsules Pharmacotherapeutic group
Paracetamol, combinations without psycholeptics.

ATX code N02B E51.

Pharmacodynamics
The drug has analgesic, antipyretic, anti-inflammatory and desensitizing activity. The mechanism of action of the main active substance of the drug – paracetamol – is due to inhibition of the synthesis of prostaglandins in the central nervous system.

Caffeine is a strong stimulant of the central nervous system, potentiates the analgesic effect of paracetamol, stimulates the respiratory and vasoconstrictor centers, promotes the expansion of the blood vessels of the muscles, heart, kidneys, vasoconstriction of the abdominal organs and the brain, reduces platelet aggregation, increases diuresis and gastric secretory activity. Caffeine enhances and accelerates the pharmacotherapeutic effect of paracetamol.

Chlorpheniramine, blocking histamine H1 receptors, has a desensitizing and analgesic effect, reduces the vascular tissue permeability of the mucous membrane of the upper respiratory tract, eliminates itching in the eyes and nose.

Ascorbic acid is a vital vitamin. It is known that ascorbic acid plays an important role in the implementation of the protective function of the body against infection and is necessary for the normal functioning of T-lymphocytes and effective phagocytic activity of leukocytes. Normalizes capillary permeability. Ascorbic acid has antioxidant properties, promotes the activation of the immune system, increases the body’s resistance to colds.

Pharmacokinetics
Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract, mainly the upper intestine. Plasma protein binding is 25%.

It is metabolized in the liver to form glucuronide and sulfate. It is excreted by the kidneys, mainly in the form of metabolites, less than 5% is excreted unchanged. Caffeine is well absorbed from the gastrointestinal tract and is evenly distributed throughout the body’s tissues. Easily penetrates the blood-brain barrier. In the process of biotransformation, it undergoes demethylation and oxidation. It is excreted from the body in the urine in the form of metabolites, a small part (about 8%) is excreted unchanged. Chlorpheniramine is well absorbed from the gastrointestinal tract, 69–72% of the drug binds to plasma proteins. The maximum concentration of the substance in the blood is reached after 2–6 hours. It is metabolized in the liver to form dimethylchlorpheniramine and didesmethylchlorpheniramine. Chlorpheniramine and its metabolites are excreted mainly by the kidneys.

Ascorbic acid is well absorbed from the small intestine, easily penetrates into leukocytes, platelets, and then into all tissues. Bioavailability is about 70%. Plasma protein binding – 24%. It is metabolized mainly in the liver. It is excreted in the form of metabolites and partially unchanged, mainly by the kidneys in the urine, as well as with feces, then it passes into breast milk.

Indications
Symptomatic treatment of colds accompanied by fever, headache, swelling of the nasal mucosa (rhinitis).

Contraindications
Hypersensitivity to the components of the drug, other xanthine derivatives (theophylline, theobromine), congenital hyperbilirubinemia, Lapp lactase deficiency or glucose-galactose malabsorption, congenital glucose-6-phosphate dehydrogenase deficiency, fructose intolerance, Dubin-Jillbert’s syndrome, Gillon’s syndrome , anemia, impaired hematopoiesis, severe hepatic or renal dysfunction, severe arterial hypertension, severe cardiovascular diseases, including rhythm disturbances, severe atherosclerosis, severe coronary heart disease, hyperthyroidism, hyperexcitability, sleep disorders, glaucoma, alcoholism, bronchial asthma, epilepsy. Thrombosis, tendency to thrombosis, thrombophlebitis, diabetes mellitus, acute pancreatitis, peptic ulcer of the stomach and duodenum in the acute stage, urolithiasis, prostatic hypertrophy with difficulty urinating, bladder neck obstruction, pyloroduodenal obstruction.