Grippocitron-Broncho oral drops solution 5 mg/ml. 20 ml. vial №1

Description

Grippocitron-Broncho 20 ml Composition
active substance: butamirate;

1 ml (22 drops) of the drug contains 5 mg citrate butamirate;

Grippocitron-Broncho 20 ml excipients:

sorbitol (E 420), glycerin, sodium saccharin, benzoic acid (E 210), vanillin, ethanol 96%, sodium hydroxide, purified water.

Dosage form
Oral drops, solution.

Basic physical and chemical properties: clear, colorless liquid with a specific odor.

Pharmacotherapeutic group
Drugs used for coughs and colds. ATX code R05D B13.

Pharmacodynamics
Centrally acting non-opiate antitussive. The active ingredient of the drug is butamirate citrate, which suppresses cough and in its structure, pharmacological action differs from opium alkaloids. It is believed that this substance acts on the central nervous system. Butamirate citrate exhibits a nonspecific anticholinergic and bronchospasmolytic effect, improves respiratory function. The drug is not addictive or addictive.

Butamirate citrate has a wide therapeutic range, so the drug is well tolerated even in high doses and is well suited as a remedy for coughing in children.

Pharmacokinetics
Butamirate is rapidly absorbed, distributed in the body, and further predominantly hydrolyzes to 2-phenylbutyric acid and diethylaminoethoxyethanol, which also have antitussive activity. 2-phenylbutyric acid is further partially metabolized by hydroxylation. Butamirate and 2-phenylbutyric acid in the body largely bind to proteins.

The effect of food on bioavailability has not been confirmed. The metabolism of butamirate to 2-phenylbutyric acid and diethylaminoethoxyethanol is proportional to the dose.

Metabolites are excreted mainly by the kidneys. Butamirate is found in urine up to 48 hours after ingestion. The half-life of butamirate is 1.48-1.93 hours, for 2 phenylbutyric acid – 23.26-24.42 hours, for diethylaminoethoxyethanol – 2.72-2.9 hours.

There is no evidence of the effect of impaired liver and kidney function on the pharmacokinetic parameters of butamirate.

Indications
Symptomatic treatment of cough (including dry) of various origins in children.

Grippocitron-Broncho 20 ml Contraindications
Hypersensitivity to the active substance or to the excipients of the drug.

Interaction with other medicinal products and other types of interactions
The simultaneous use of expectorants should be avoided.

Application features
Since butamirate suppresses the cough reflex, the simultaneous use of expectorants should be avoided, since this can lead to stagnation of mucus in the airways, increasing the risk of bronchospasm and respiratory tract infection.

If a patient has an established intolerance to some sugars, a doctor should be consulted before taking this medication.

The drug contains a small amount of ethanol (alcohol), less than 100 mg / dose.

If the cough persists for more than 7 days, then you need to see a doctor.

The ability to influence the reaction rate when driving or operating machinery
The drug is intended for use in children. Rarely, the drug may cause drowsiness, which may have some effect on the ability to drive vehicles or operate machinery. Therefore, you should be careful when driving or performing other work that requires vigilance (for example, when operating machinery).