$18.00
Manufacturer: Ukraine
Increased individual sensitivity to any components of the drug or to other antihistamines; severe violations of liver and kidney function; congenital deficiency of glucose-6-phosphate dehydrogenase (as evidenced by hemolytic anemia); severe cardiac conduction disorders; uncompensated heart failure; hyperthyroidism; obstruction of the bladder neck; pyloroduodenal obstruction; intolerance to fructose, galactose; glucose-galactose malabsorption syndrome, lactase or sucrose-isomaltase deficiency; thrombosis; thrombophlebitis; the tendency to thrombosis; congenital hyperbilirubinemia; glaucoma; alcoholism; violation of hematopoiesis; blood disease; severe leukopenia; anemia; peptic ulcer of the stomach and duodenum in the acute stage.
Description
Grippocitron powder Composition
active ingredients: paracetamol; ascorbic acid (vit C) pheniramine; phenylephrine;
1 packet contains paracetamol 500 mg, ascorbic acid 50 mg, pheniramine maleate 20 mg, phenylephrine hydrochloride 10 mg;
excipients: sorbitol (E 420), citric acid, sodium saccharin, lactose, succinic acid, sodium, povidone, colloidal silicon dioxide, tartrazine (E 102); flavoring “Lemon” containing maltodextrin, gum arabic, citric acid.
Grippocitron powder Dosage form
Powder for oral solution.
Basic physical and chemical properties: the contents of the package are a mixture of granules and powder of yellow and white color with a fruity odor.
Grippocitron powder Pharmacotherapeutic group
Analgesics and antipyretics. Paracetamol, combinations without psycholeptics. ATX code N02B E51.
Pharmacodynamics
Paracetamol has antipyretic, analgesic and mild anti-inflammatory effects. Suppresses the synthesis of prostaglandins in the central nervous system (CNS) and blocks the conduction of pain impulses.
Ascorbic acid enhances the body’s nonspecific resistance.
Pheniramine maleate – a blocker of H1-receptors, reduces vascular permeability, eliminates lacrimation, itching of the eyes and nose.
Phenylephrine hydrochloride is an α-adrenergic agonist, has a vasoconstrictor effect, reduces swelling of the nasal mucosa and paranasal sinuses.
Pharmacokinetics
Paracetamol is well absorbed, penetrates the placental barrier, enters breast milk in small amounts, is metabolized by the cytochrome P450 system, is excreted by the kidneys, the half-life (T ½) is 1-4 hours. The duration of action is 3-4 hours.
Ascorbic acid is rapidly absorbed in the digestive tract. It is metabolized in the liver, excreted by the kidneys.
Pheniramine maleate is well absorbed in the digestive tract. It is metabolized in the liver by the cytochrome P450 system, T ½ – 16-18 hours, 70-83% is excreted by the kidneys.
The effect of phenylephrine hydrochloride is rapid and lasts about 20 minutes. It is metabolized in the liver or in the digestive tract, excreted by the kidneys.
Indications
Symptomatic treatment of acute respiratory infections and influenza:
Increased body temperature.
Headache.
Nasal congestion.
Runny nose.
Muscle aches and pains.
Contraindications
Hypersensitivity to the components of the drug, severe impairment of liver and / or kidney function; congenital hyperbilirubinemia; deficiency of glucose-6-phosphate dehydrogenase; phenylketonuria, alcoholism, blood diseases, leukopenia, anemia, severe arrhythmias, arterial hypertension, atherosclerosis, coronary heart disease, hyperthyroidism, acute pancreatitis, prostate hypertrophy with urinary retention, bladder neck obstruction, pyloroduodenal obstruction; bronchial asthma; glaucoma; pheochromocytoma; thrombosis; thrombophlebitis; epilepsy, states of increased excitement; sleep disturbance, concomitant treatment with tricyclic antidepressants, β-blockers, other sympathomimetics, drugs that suppress or increase appetite, and amphetamine-like psychostimulants; concomitant treatment and 2 weeks after the use of MAO inhibitors.
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