Grippostad Rino 0.05% nasal drops 10 ml. vial

Description

Grippostad Rino 0.05% Storage:

active substance: xylometazoline hydrochloride;

1 ml of solution contains xylometazoline hydrochloride 0.5 mg;

excipients: benzalkonium chloride solution; citric acid, monohydrate; sodium citrate; glycerin (85%); purified water.

Grippostad Rino 0.05% Dosage form.

Nasal drops, solution.

Main physical and chemical properties: transparent, almost colorless solution, does not contain visible excess particles, odorless.

Pharmacotherapeutic group. Anti-edema drugs for topical use in diseases of the nasal cavity. Sympathomimetics, simple drugs. ATX code R01A A07.

Grippostad Rino 0.05% Pharmacological properties.

Pharmacodynamics.

Xylometazoline is an imidazoline derivative, an alpha-adrenergic sympathomimetic. Directly stimulates alpha-adrenoceptors and narrows blood vessels. When applied topically, it reduces swelling of the nasopharyngeal mucosa. Restores patency of the nasal passages and facilitates nasal breathing by decongesting the mucous membrane and improving the drainage of secretions.

The drug begins to act after 5-10 minutes and continues to act for several hours
(average 6-8 hours).

When administered intranasally, the amount of drug absorbed may sometimes be sufficient to develop systemic effects, for example, in the central nervous system and cardiovascular system.

Pharmacokinetics.

When applied topically, xylometazoline is practically undetectable in blood plasma (plasma concentration is less than the limit of determination).

Clinical characteristics.

Indication.

Symptomatic treatment of nasal congestion with colds, hay fever, other allergic rhinitis, sinusitis.

To facilitate the outflow of secretions in diseases of the paranasal sinuses.

Adjuvant therapy in cases of otitis media (to eliminate mucosal edema).

To facilitate rhinoscopy.

Contraindication.

Hypersensitivity to xylometazoline or to any other component of the drug, angle-closure glaucoma, transphenoidal hypophysectomy and surgery to expose the meninges in the anamnesis, dry rhinitis (rhinitis sicca) or atrophic rhinitis.

Special security measures.

GRIPPOSTAD® RINO 0.05% NOSE DROPS should not be used in children under 1 year of age. Use in children aged 1 to 11 years is recommended only under adult supervision

The drug should not be used in children longer than 7-10 consecutive days. Prolonged or excessive use may lead to recurrence of nasal congestion and / or atrophy of the nasal mucosa.

The drug, like other sympathomimetics, should be used with caution in patients who have severe reactions to adrenergic drugs, manifested as insomnia, dizziness, tremor, cardiac arrhythmia or increased blood pressure.

Do not exceed the recommended dose, especially in the treatment of children and the elderly.