Grippostad S capsules №10

Description

Grippostad S Storage
active substances: 1 capsule contains paracetamol 200 mg; ascorbic acid 150 mg; caffeine 25 mg; chlorphenamine maleate 2.5 mg;

excipients: lactose monohydrate; gelatin; glycerol tristearate; titanium dioxide (E 171); quinoline yellow (E 104); erythrosine (E 127).

Grippostad S Dosage form
Hard capsules.

Main physical and chemical properties: hard gelatin capsules, size 1, lid: yellow opaque, body: white opaque, capsule content: powder from white to yellowish.

Grippostad S Pharmacotherapeutic group
Paracetamol, combinations without psycholeptics. ATX code N02B E51.

Pharmacological properties
Paracetamol is an analgesic and antipyretic (analgesic and antipyretic). The effect is based on the inhibition of prostaglandin synthesis in the central nervous system. Paracetamol is rapidly and almost completely absorbed in the gastrointestinal tract. The maximum concentration in blood plasma is reached in 30-60 minutes. The half-life is 1-4 hours. Evenly distributed in all body fluids. Plasma protein binding is variable. It is excreted mainly by the kidneys in the form of conjugated metabolites.

Chlorphenamine maleate – a classic H1-antihistamine, which has a desensitizing and analgesic effect, reduces vascular permeability of the mucous membrane of the upper respiratory tract, eliminates itching in the eyes and nose.

Chlorpheniramine is well absorbed from the gastrointestinal tract, 69-72% of the drug binds to plasma proteins. The maximum concentration of the substance in the blood is reached in 2-6 hours. Metabolized in the liver. Chlorpheniramine and its metabolites are excreted mainly by the kidneys.

Caffeine is a strong stimulant of the central nervous system, potentiates the analgesic effect of paracetamol, stimulates the respiratory and vasoconstrictor centers, dilates blood vessels of muscles, heart, kidneys, narrows the vessels of the abdominal cavity and brain, reduces platelet aggregation and increases platelet aggregation and increases.

Ascorbic acid is a vital vitamin. It is known that ascorbic acid plays an important role in the implementation of the body’s protective function against infection and is necessary for the normal functioning of T lymphocytes and effective phagocytic activity of leukocytes. Normalizes capillary permeability.

Ascorbic acid is easily absorbed in the gastrointestinal tract. 25% is bound to blood proteins. It is metabolized in the liver mainly to dehydroascorbic acid. Ascorbic acid and its metabolites are excreted in the urine and bile. Residual ascorbic acid, which exceeds the body’s needs, is excreted in the urine as metabolites.

Indication
To relieve cold symptoms.

Contraindication
Hypersensitivity to paracetamol or to any other component of the drug; severe hepatic and / or renal impairment, Gilbert’s syndrome, Dubin-Johnson syndrome, congenital hyperbilirubinemia, glucose-6-phosphate dehydrogenase deficiency; alcoholism; blood diseases, severe anemia, leukopenia; hematopoietic disorders; thrombosis, thrombophlebitis; increased excitability, sleep disorders; severe hypertension, marked increase in blood pressure, tendency to vasospasm, in organic diseases of the cardiovascular system (including atherosclerosis), decompensated heart failure, severe conduction disorders and arrhythmias; epilepsy; hyperthyroidism; hypertrophy of the prostate, obstruction of the bladder neck; diabetes; angle-closure glaucoma; acute pancreatitis, peptic ulcer of the stomach and duodenum in the acute stage, pyloroduodenal obstruction, myocardial infarction, paroxysmal tachycardia, hypersensitivity to other antihistamines; predisposition to thrombosis, age over 60 years.

Do not use together with monoamine oxidase inhibitors (MAO) and within 2 weeks after discontinuation of MAO inhibitors, do not use with tricyclic antidepressants or β-blockers.