Description

Griseofulvin Tablets 0.125 g. №40

Ingredients

Each tablet contains 0.125 g of Griseofulvin.

Mechanism of Action

Griseofulvin exerts its antifungal effects by disrupting the microtubule function in fungal cells, inhibiting mitosis and leading to the prevention of fungal cell division.

Pharmacological Properties

Griseofulvin is a fungistatic agent that selectively binds to keratin precursor cells, making it effective in treating infections of the skin, hair, and nails caused by dermatophytes.

Indications for Use

Griseofulvin is indicated for the treatment of superficial fungal infections including tinea corporis, tinea cruris, tinea capitis, and onychomycosis.

Contraindications

Avoid using Griseofulvin in patients with a history of porphyria, hepatocellular failure, or hypersensitivity to the drug. Caution is advised in pregnant or lactating women.

Side Effects

• Gastrointestinal disturbances
• Headache
• Dizziness
• Skin rashes
• Hepatotoxicity (rare)

Usage Instructions

The typical adult dosage ranges from 500 mg to 1 g daily, administered in divided doses. The duration of treatment may vary depending on the type and severity of the fungal infection.

Benefits Compared to Analogues

Griseofulvin offers the advantage of targeting fungal infections of the skin, hair, and nails with a specific mechanism of action, reducing the risk of developing resistance compared to other antifungal agents.

Suitable Patient Groups

Griseofulvin is generally safe for use in adults, children, and elderly patients; however, individual dosage adjustments may be necessary based on age, weight, and renal function.

Storage and Shelf Life

Store Griseofulvin tablets in a cool, dry place away from direct sunlight. Check the expiration date on the packaging and do not use the medication after the specified shelf life.

Packaging Description

Each package contains 40 tablets of Griseofulvin 0.125 g, sealed for protection. The packaging should be kept intact until the tablets are consumed to prevent exposure to moisture and contaminants.

Scientific Evidence

Griseofulvin has demonstrated efficacy in clinical studies for treating various dermatophyte infections, showing significant improvement in symptoms and mycological cure rates. Studies have highlighted its effectiveness in cases of tinea capitis and tinea corporis.

Additional Information

Patients are advised to complete the full prescribed course of Griseofulvin to ensure complete eradication of the fungal infection and prevent recurrence or resistance development. Consult your healthcare provider before starting Griseofulvin if you are on other medications to avoid potential drug interactions.