Grizeofulvin tablets 0.125 g. №40

$7.00

Manufacturer: Ukraine

Mycosis of the skin, hair and nails caused by fungi of the genus Trichophyton, Microsporum, Epydermophyton: trichophytia, favus, microsporia of the scalp and smooth skin, epidermophytia of the skin (including inguinal epidermophytia), dermatomycosis of the feet and hands, onychomycosis.

Category:

Description

Grizeofulvin №40 Composition
active substance: griseofulvin;

1 tablet contains 125 mg griseofulvin;

excipients: lactose monohydrate, corn starch, polyethylene glycol, povidone, magnesium stearate.

Grizeofulvin №40 Dosage form
Pills.

Basic physical and chemical properties: tablets of white or white color with a yellowish tinge, round in shape with a biconvex surface. Marbling is allowed on the surface of the tablets.

Grizeofulvin №40 Pharmacotherapeutic group
Antifungal drugs for systemic use. ATX code D01B A01.

Pharmacodynamics
Griseofulvin is an antibiotic produced by the mold Penicillinum nigricans, a fungistatic agent that is active against various dermatomycetes (trichophytos, microsporums, epidermophytos). The drug inhibits the division of fungal cells in metaphase, disrupting the structure of the mitotic spindle. griseofulvin accumulates to varying degrees in the cells of the skin, hair, nails, providing resistance to fungal infection. With the death of the affected keratin, it is replaced with healthy ones.

Pharmacokinetics
It is metabolized in the liver with the formation of the main metabolites: 6-methylgriseofulvin and a glucuronide derivative. The half-life is 24 hours. It is excreted by the kidneys. Less than 1% is excreted unchanged in urine, 36% in feces.

Indications
Mycoses of the skin, hair and nails caused by fungi of the genus Trichophyton, Microsporum, Epydermophyton: trichophytosis, favus, microsporia of the scalp and smooth skin, epidermophytosis of the skin (including epidermophytosis inguinal), dermatomycosis of the feet and hands, onychomycosis.

Contraindications
hypersensitivity to griseofulvin and to other components of the drug;
severe leukopenia and systemic blood diseases;
severe liver and kidney disease;
porphyria;
systemic lupus erythematosus;
malignant neoplasms;
lactase deficiency, galactosemia, glucose-galactose malabsorption syndrome (the drug contains lactose).

Method of administration and dosage
Take the tablets during or after meals (with 1 teaspoon of vegetable oil).

For microsporia, adults should be prescribed 1 g of griseofulvin per day. It is desirable to divide the daily dose into 2 doses.

The drug should be taken daily until the first negative mycological test result, then – in the same dose for 2 weeks every other day and 4 times – over the next 2 weeks.

In case of onychomycosis, trichophytosis, favus of the scalp, the daily dose of griseofulvin for adults weighing up to 50 kg is 625 mg (5 tablets), with a larger weight, prescribe an additional 125 mg for every 10 kg.

The period of treatment for severe mycoses can last up to 12 months. The course of treatment for lesions of the skin of the body – 2-4 weeks, scalp – 4-6 weeks, skin of the feet – 4-8 weeks, fingernails – at least 4 months, toenails – at least 6 months.

Take the drug until complete clinical and laboratory recovery.