Gropivirin tablets 500 mg. №50

Description

Gropivirin Composition
Active ingredient: inosine pranobex.

1 tablet contains 500 mg of inosine pranobex.

Excipients:

corn starch, mannitol (E 421), povidone (Kollidon 25), magnesium stearate.

Gropivirin Dosage form
Pills.

Basic physical and chemical properties: tablets from almost white to yellowish-white color, oval, biconvex, oblong, with a risk on one side, with a slight specific odor.

Gropivirin Release form
There are 10 tablets in a blister. 2 or 5 blisters per pack.

Active substance
Inosine pranobex

Pharmacodynamics
Gropivirin is an antiviral agent with immunomodulatory properties. The drug normalizes (to the individual norm) deficiency or dysfunction of cellular immunity, inducing the maturation and differentiation of T-lymphocytes and T1-helpers, potentially induction of lymphoproliferative responses in mitogenic or antigen-active cells. Gropivirin models the cytotoxicity of T-lymphocytes and natural killer cells, the function of T8-suppressors and T4-helpers, and also increases the amount of immunoglobulin G and surface markers of the compliment. Gropivirin increases the synthesis of interleukin-1 (IL-1) and the synthesis of interleukin-2 (IL-2), regulates the expression of IL-2 receptors. Gropivirin significantly increases the secretion of endogenous interferon gamma and reduces the production of interleukin-4 in the body. Gropivirin enhances the action of neutrophilic granulocytes, chemotaxis and phagocytosis of monocytes and macrophages. Gropivirin inhibits the synthesis of the virus by incorporating inosine-orotic acid into the polyribosome of the cell affected by the virus and inhibits the attachment of adenic acid to the viral i-RNA.

Pharmacokinetics
After taking the drug orally at a dose of 1.5 g, the maximum concentration of inosine pranobex in the blood plasma is reached after 1 hour and is 600 μg / ml. In the body of inosine, pranobex is metabolized in the liver to form uric acid. The half-life of 4- (acetylamino) benzoate is 50 minutes, for 1- (dimethylamino) -2-propanol – 3.5 hours. It is excreted by the kidneys in the form of metabolites.

Indications
– viral infections caused by herpes simplex virus types 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, measles virus, mumps virus, including in patients with immunodeficiency states;
– viral respiratory infections;
– papillomavirus infections of the skin and mucous membranes: genital warts, papillomavirus infection of the vulva, vagina and cervix (as part of complex therapy);
– acute viral encephalitis (as part of complex therapy);
– viral hepatitis (as part of complex therapy);
– subacute sclerosing panencephalitis (as part of complex therapy).

Contraindications
Hypersensitivity to any component of the drug, gout, hyperuricemia.
Interaction with other medicinal products
You should not take the drug at the same time as immunosuppressants. Care should be taken to prescribe a drug with xanthine oxidase inhibitors and agents that promote the excretion of uric acid, including diuretics – thiazide diuretics (for example, hydrochlorothiazide, chlorthalidone, indapamide) and loop diuretics (for example, furosemide, torasemide, ethacrynic acid).

With simultaneous use with azidothymidine, nucleotide formation increases due to an increase in the bioavailability of azidothymidine in blood plasma and an increase in intracellular phosphorylation in human blood monocytes.