Description
Hartil-AM (Ramipril + Amlodipine) Capsules 5 mg/5 mg. №30
Composition
The active ingredients in Hartil-AM are Ramipril and Amlodipine. Each capsule contains 5 mg of each active ingredient.
Mechanism of Action
Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, and Amlodipine, a calcium channel blocker, work synergistically to lower blood pressure. Ramipril inhibits the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, leading to vasodilation and reduced peripheral resistance. Amlodipine blocks calcium influx into vascular smooth muscle cells, resulting in vasodilation and decreased systemic vascular resistance.
Pharmacological Properties
Hartil-AM combines the antihypertensive effects of Ramipril and Amlodipine to effectively manage hypertension. Ramipril’s ACE inhibition and Amlodipine’s calcium channel blocking properties provide a comprehensive approach to blood pressure control.
Indications for Use
Hartil-AM is indicated for the treatment of hypertension (high blood pressure). It is suitable for both initial therapy and as an adjunct to other antihypertensive agents to achieve optimal blood pressure control.
Contraindications
Hartil-AM is contraindicated in patients with a known hypersensitivity to Ramipril, Amlodipine, or any other component of the formulation. It should not be used in individuals with severe renal impairment, aortic stenosis, or unstable angina due to potential risks of exacerbation of these conditions.
Side Effects
Common side effects of Hartil-AM may include dizziness, headache, peripheral edema, cough, and flushing. Serious but rare side effects may include angioedema, hypotension, and renal dysfunction. Patients should seek medical attention if they experience any severe or persistent adverse reactions.
Usage Instructions
The recommended dosage of Hartil-AM is one capsule per day, to be taken orally with a full glass of water. It is important to adhere to the prescribed dose and not exceed the recommended amount. If a dose is missed, it should be taken as soon as remembered, unless it is close to the next scheduled dose.
Benefits Compared to Analogues
Hartil-AM offers the advantage of dual therapy with Ramipril and Amlodipine in a single capsule, providing convenience and enhanced compliance for patients requiring combination antihypertensive treatment. The synergistic action of these two agents allows for effective blood pressure control with potentially fewer side effects compared to using multiple individual medications.
Suitable Patient Groups
Hartil-AM is suitable for adult patients with hypertension, including elderly individuals who may benefit from the combination therapy’s efficacy and tolerability profile. It is not recommended for use in children or adolescents due to limited data on safety and efficacy in this population.
Storage and Shelf Life
Hartil-AM should be stored at room temperature away from moisture and heat. The shelf life of the product is indicated on the packaging and should be checked before use to ensure the medication’s potency and safety.
Packaging Description
Hartil-AM is available in blister packs containing 30 capsules. Each capsule is clearly labeled with the product name, active ingredients, dosage strength, and other relevant information. The packaging is designed to protect the capsules from environmental factors and maintain their stability until use.
