Description
Hartil Tablets 10 mg. №28
Ingredients
The active ingredient in Hartil tablets is 10 mg of Ramipril. Other ingredients include microcrystalline cellulose, pregelatinized starch, and sodium stearyl fumarate.
Mechanism of Action
Ramipril, the active ingredient in Hartil tablets, is an angiotensin-converting enzyme (ACE) inhibitor. It works by inhibiting ACE, which is involved in the production of angiotensin II. By blocking the formation of angiotensin II, Ramipril helps dilate blood vessels, reduce sodium retention, and decrease aldosterone levels, ultimately leading to decreased blood pressure and improved cardiac function.
Pharmacological Properties
Ramipril is rapidly absorbed after oral administration, with peak plasma concentrations reached within 1 to 2 hours. It undergoes hepatic metabolism to its active metabolite, ramiprilat, which is responsible for its pharmacological effects. The elimination half-life of ramipril is approximately 13 to 17 hours, allowing for once-daily dosing.
Indications for Use
Hartil tablets are indicated for the treatment of hypertension and congestive heart failure. Additionally, they are prescribed to reduce the risk of stroke and myocardial infarction in patients at high cardiovascular risk.
Contraindications
- Patients with a history of angioedema related to previous treatment with an ACE inhibitor should not use Hartil tablets.
- Individuals with hypersensitivity to any component of the product, including ramipril, should avoid its use.
- Patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney should not take Hartil tablets.
Side Effects
Common side effects of Hartil tablets may include cough, dizziness, hypotension, and hyperkalemia. Rare but serious side effects may include angioedema, renal impairment, and neutropenia. Patients should consult their healthcare provider if they experience any adverse reactions while taking this medication.
Usage Instructions
The recommended starting dose of Hartil tablets is one 10 mg tablet daily. The dosage may be adjusted by the physician based on the individual patient’s response. The tablets should be taken orally, preferably at the same time each day, with a full glass of water. They can be administered with or without food.
Benefits Compared to Analogues
Hartil tablets offer the advantage of once-daily dosing, thanks to the long elimination half-life of ramipril. This convenience enhances patient adherence to treatment regimens and may contribute to better blood pressure control and cardiovascular outcomes compared to medications requiring more frequent dosing.
Suitable Patient Groups
Hartil tablets are suitable for adult patients with hypertension, congestive heart failure, or at high risk of cardiovascular events. However, special caution should be exercised when prescribing this medication to elderly individuals and those with impaired renal function. Pediatric use of Hartil tablets is not recommended due to limited data on safety and efficacy in children.
Storage and Shelf Life
Hartil tablets should be stored at room temperature, away from moisture and light. The shelf life of the product is typically indicated on the packaging and should be checked before use. Unused tablets should be properly disposed of according to local regulations.
Packaging Description
Hartil tablets are typically packaged in blister packs containing 28 tablets. The packaging should be kept intact until the tablets are ready to be used. Each tablet is imprinted with the dosage strength for easy identification.
