Ibufen forte oral suspension 200 mg/5 ml. 100 ml. Vial №1

Description

Ibufen 200 mg Composition
active substance: ibuprofenum;

5 ml of suspension contains 100 mg of ibuprofen;

d excipients: hypromellose, xanthan gum, glycerin, sodium benzoate (E 211), liquid maltitol, sodium, citric acid, sodium saccharin, sodium chloride, raspberry flavor, purified water.

Ibufen 200 mg Dosage form
Oral suspension.

Basic physical and chemical properties: a homogeneous suspension of white or almost white color with a homogeneous opalescence and a raspberry smell.

Ibufen 200 mg Pharmacotherapeutic group
Non-steroidal anti-inflammatory drugs. Propionic acid derivatives. ATX code М01А Е01.

Pharmacodynamics
Ibufen® for children, raspberry has antipyretic, analgesic and anti-inflammatory effects.

The mechanism of antipyretic action is realized due to the central and peripheral components. The action of Ibufen® for children, raspberry is to block the cyclooxygenase of arachidonic acid in the central nervous system (CNS). This leads to a decrease in the synthesis of prostaglandins, as a result of which the body temperature is normalized. The peripheral component of the antipyretic action of Ibufen® for children, raspberry, is due to inhibition of the processes of creating prostaglandins in damaged tissues, which causes a decrease in the activity of inflammation.
After oral administration, more than 80% of ibuprofen is absorbed in the gastrointestinal tract, reaching a maximum concentration in blood plasma after 1-2 hours. Binds to blood plasma proteins (mainly albumin) by more than 90%. The drug slowly penetrates into the joint cavity. The maximum concentration in the synovial fluid is observed 5-6 hours after oral administration.

It is metabolized in the liver to two inactive metabolites, rapidly and almost completely excreted by the kidneys.

Does not accumulate in the body. 60-90% is excreted in the urine in the form of metabolites and their products in conjunction with glucuronic acid. A certain amount (10%) is displayed unchanged. The half-life is 2 hours. After taking a single dose, the drug is completely excreted within 24 hours.

Indications
Symptomatic treatment of fever and pain of various origins in children aged 3 months to 12 years with a body weight of at least 5 kg (including fever after immunization, acute respiratory viral infections, influenza, pain during teething, pain after tooth extraction, toothache, headache, sore throat, sprain pain, and other types of pain whether, including inflammatory genesis).

Contraindications
Hypersensitivity to ibuprofen or to any of the components of the drug;
a history of hypersensitivity reactions (eg, bronchospasm, bronchial asthma, rhinitis, angioedema or urticaria) after using ibuprofen, acetylsalicylic acid or other NSAIDs;
peptic ulcer and duodenal ulcer / bleeding in active form or relapses in history (two or more severe episodes of confirmed peptic ulcer or bleeding);
a history of gastrointestinal bleeding or perforation associated with the use of NSAIDs;
severe liver failure, severe renal failure, or severe heart failure (NYHA functional class IV);
severe dehydration (due to vomiting, diarrhea, or insufficient fluid intake);