Ibufen Junior soft capsules 200 mg. №10

Description

Ibufen Junior Storage
active substance: ibuprofenum;

1 soft capsule contains ibuprofen 200 mg;

excipients: macrogol 600 (E 1521), potassium hydroxide (E 525), purified water;

gelatin capsule: liquid maltitol (E 965), sorbitol non-crystallizing solution (E 420), gelatin (E 441), purified water.

Ibufen Junior Dosage form
The capsules are soft.

Main physical and chemical properties: oval-shaped soft gelatin capsules with a translucent shell of light yellow color, containing a viscous liquid.

Ibufen Junior Pharmacotherapeutic group
Non-steroidal anti-inflammatory and anti-rheumatic drugs. Derivatives of propionic acid. ATX code M01A E 01.

Pharmacological properties

Pharmacodynamics.

Ibuprofen is a derivative of propionic acid. Has analgesic, antipyretic and anti-inflammatory effects.

The mechanism of action of ibuprofen is primarily due to the inhibition of prostaglandin biosynthesis by reducing the activity of cyclooxygenase (COX) – an enzyme that regulates the conversion of arachidonic acid to prostaglandins, prostacyclin and thromboxane. The formation of prostaglandins is reduced as a result of irreversible inhibition of the cyclooxygenase pathway of arachidonic acid metabolism. The decrease in the concentration of prostaglandins at the site of inflammation is accompanied by a decrease in the formation of bradykinin, endogenous pyrogens, other biologically active substances, oxygen radicals and NO. All this leads to a decrease in the activity of the inflammatory process (anti-inflammatory effect of ibuprofen) and is accompanied by a decrease in pain reception (analgesic effect). Decreasing the concentration of prostaglandins in the cerebrospinal fluid leads to normalization of body temperature (antipyretic effect).

Pharmacokinetics.

Ibufen® Junior soft gelatin capsules contain liquid ibuprofen. Gelatin capsule provides high accuracy of dosing of substances contained in them. The capsule shell protects the active substance from light, air and moisture, as well as masks the unpleasant taste and odor of the drug when taken. The capsule dissolves in the gastrointestinal tract (GI tract) faster than pills and tablets, and its liquid content is absorbed faster and easier in the human body, providing high bioavailability of ibuprofen.

After oral administration, more than 80% of ibuprofen is absorbed from the digestive tract. 90% of the drug binds to plasma proteins (mainly albumin).

The period of reaching the maximum concentration in blood plasma when taken on an empty stomach is 45 minutes, when taken after a meal – 1.5-2.5 hours; in synovial fluid – 2-3 hours, where higher concentrations are created than in blood plasma.

The drug does not accumulate in the body.

Ibuprofen is metabolized mainly in the liver. Subject to presystemic and postsystemic metabolism. After absorption, about 60% of the pharmacologically inactive R-form of ibuprofen is slowly transformed into the active S-form.

60-90% of the drug is excreted by the kidneys in the form of metabolites and products of their binding to glucuronic acid, to a lesser extent – with bile, and unchanged excreted no more than 1%. After taking a single dose, the drug is completely eliminated within 24 hours.

Indication
Symptomatic treatment of headache (including migraine), toothache, dysmenorrhea, neuralgia, back pain, joints, muscles, rheumatic pain, and signs of colds and flu.

Contraindication
Hypersensitivity to ibuprofen and other non-steroidal anti-inflammatory drugs or to any of the components of the drug.
Hypersensitivity reactions (such as asthma, rhinitis, angioneurotic edema, or urticaria) previously seen with ibuprofen, acetylsalicylic acid (aspirin), or other NSAIDs.
Gastric or duodenal ulcer / bleeding in active form or recurrence in the anamnesis (two or more pronounced episodes of confirmed peptic ulcer disease or bleeding).
History of gastrointestinal bleeding or perforation associated with NSAID use.
Severe heart failure (NYHA class IV), severe renal failure or severe hepatic failure.
The last trimester of pregnancy.
Active inflammatory bowel disease.
Cerebrovascular or other bleeding.
Hematopoietic disorders or blood clotting of unknown etiology (hemorrhagic diathesis, thrombocytopenia).
Dehydration caused by vomiting, diarrhea, or insufficient fluid intake.