Description

Imipenem/Cilastatin Powder for Solution for Injections 500 mg/500 mg. №10

Ingredients:

Each vial contains: Imipenem (as monohydrate) 500 mg and Cilastatin (as sodium) 500 mg.

Dosage:

The usual dose is: 500 mg imipenem/500 mg cilastatin every 6 hours by intravenous infusion over 20 to 40 minutes.

Indications:

Imipenem/Cilastatin is indicated for the treatment of severe infections caused by susceptible strains of microorganisms.

Contraindications:

Do not use if there is a history of hypersensitivity to imipenem, cilastatin, or any component of the product.

Directions:

Administer by intravenous route only. Follow reconstitution and dilution instructions before use.

Scientific Evidence:

Imipenem/Cilastatin has demonstrated efficacy in various clinical trials for the treatment of complicated intra-abdominal infections, skin and soft tissue infections, and urinary tract infections. Studies have shown a high success rate in eradicating pathogens and improving clinical outcomes.

Additional Information:

Imipenem/Cilastatin exhibits a broad spectrum of antibacterial activity by inhibiting cell wall synthesis in bacteria. The combination of imipenem with cilastatin prevents the breakdown of imipenem by renal dehydropeptidase, extending its half-life and enhancing its effectiveness.

Comparative studies have shown that Imipenem/Cilastatin is as effective as or superior to other antibiotics in the treatment of severe infections, making it a valuable option in clinical practice.