Description

Imipenem/Cilastatin Powder for Solution for Injections 500 mg/500 mg. №10

Ingredients:

Each vial contains: Imipenem (as monohydrate) 500 mg and Cilastatin (as sodium) 500 mg.

Mechanism of Action:

Imipenem/Cilastatin exerts bactericidal activity by inhibiting cell wall synthesis in susceptible bacteria, ultimately leading to cell death.

Pharmacological Properties:

Imipenem, a carbapenem antibiotic, disrupts bacterial cell wall synthesis. Cilastatin functions by inhibiting renal dehydropeptidase, thereby preventing the degradation of imipenem and enhancing its pharmacological effects.

Indications for Use:

Imipenem/Cilastatin is indicated for the treatment of severe infections caused by susceptible microorganisms, including complicated intra-abdominal infections, skin and soft tissue infections, and urinary tract infections.

Contraindications:

Contraindications: This product should not be used in patients with a history of hypersensitivity to imipenem, cilastatin, or any component of the formulation.

Side Effects:

Common side effects may include nausea, vomiting, diarrhea, rash, and hypersensitivity reactions. Rare but severe side effects such as Clostridium difficile-associated diarrhea and seizures can occur.

Usage Instructions:

Administration: This product is for intravenous use only. It should be reconstituted and diluted according to the provided instructions before administration.

Dosage: The typical dosage is 500 mg imipenem/500 mg cilastatin every 6 hours via intravenous infusion lasting 20 to 40 minutes.

Benefits Compared to Analogues:

Imipenem/Cilastatin has demonstrated equal or superior efficacy compared to other antibiotics in the treatment of severe infections, offering a valuable therapeutic option for healthcare providers.

Suitable Patient Groups:

Imipenem/Cilastatin can be used in adult patients, including the elderly, for the treatment of severe infections caused by susceptible organisms. Dosage adjustments may be necessary for patients with renal impairment.

Storage and Shelf Life:

It is essential to store this product at the recommended temperature and shield it from light. Always verify the expiration date on the packaging and refrain from using it post the specified shelf life.

Packaging Description:

The product is supplied in vials containing 500 mg of imipenem and 500 mg of cilastatin powder for reconstitution. Each package comprises 10 vials.

Clinical Evidence and Proven Effectiveness:

Imipenem/Cilastatin has exhibited efficacy in clinical trials for treating various infections, demonstrating a high success rate in pathogen eradication and enhancing clinical outcomes.