Indapen coated tablets 2.5 mg. №30

Description

INDAPEN COMPOSITION
active substance: indapamide

1 coated tablet contains 2.5 mg indapamide

Excipients: microcrystalline cellulose, crospovidone, magnesium stearate

shell: microcrystalline cellulose, hypromellose, stearic acid, titanium dioxide (E 171).

INDAPEN DOSAGE FORM
Film-coated tablets.

INDAPEN MAIN PHYSICAL AND CHEMICAL PROPERTIES:
tablets are white, round, biconvex, with a rough surface.

PHARMACOLOGICAL GROUP
Non-thiazide diuretics with moderate diuretic activity. Sulfonamides, simple drugs. Indapamide.

code АТХС0ЗВ А11.

PHARMACOLOGICAL PROPERTIES.
Pharmacological.

Indapamide is a sulfonamide diuretic that is pharmacologically related to thiazide diuretics. Indapamide inhibits sodium reabsorption in the cortical segment of the kidney. This increases the excretion of sodium and chloride in the urine and, to a lesser extent, the excretion of potassium and magnesium, thus increasing urine output. The antihypertensive effect of indapamide is manifested at doses at which the diuretic effect is negligible. Moreover, its antihypertensive effect persists even in hypertensive hemodialysis patients.

Indapamide has a high lyophilicity and lyophobicity and acts at the level of the vascular wall, namely:

changes the transmembrane flow of ions (primarily calcium), which leads to a decrease in the contractility of smooth muscles in blood vessels, stimulates the synthesis of prostaglandin PGE 2 and prostacyclin PGI 2, which is a vasodilator and inhibitor of platelet aggregation). All this leads to a decrease in the total resistance of peripheral vessels and arterioles and causes a decrease in blood pressure.
Indapamide reduces left ventricular hypertrophy.

With short-term, medium-term and long-term observation of patients with arterial hypertension, it has been shown that indapamide:

does not affect the metabolism of lipids: triglycerides, LDL cholesterol and HDL cholesterol
does not affect the metabolism of carbohydrates, even in patients with arterial hypertension and diabetes mellitus.

Pharmacokinetics.

After oral administration, indapamide is rapidly and completely absorbed, the peak blood concentration is reached after 1-2 hours. Indapamide accumulates in erythrocytes and binds to plasma proteins and erythrocytes by 71-79%. The half-life (t 0.5) is approximately 15 hours. The state of dynamic equilibrium is reached after 4 days. Due to its high solubility in lipids, the drug penetrates through the walls to the vessels of smooth muscle fibers.

Renal clearance is 60-80% of the total clearance. Most of the indapamide is metabolized, 5-7% of the substance is found in the urine unchanged. With feces, 20-30% of the administered dose is excreted.

INDICATIONS
Arterial hypertension.

CONTRAINDICATIONS
Hypersensitivity to indapamide, to any other components of the drug, or to other sulfonamides. Severe renal failure. Hepatic encephalopathy and severe liver dysfunction. Hypokalemia.