Indapen SR coated tablets with modified release 1.5 mg. №30

Description

Indapen SR Composition

active substance: indapamide
1 tablet contains 1.5 mg indapamide
Excipients: lactose, carbomer, hydroxypropyl methylcellulose, magnesium stearate, colloidal silicon dioxide, talc
Sheath opadry ii pink (33 g24509): hypromellose, titanium dioxide (E 171), lactose, macrogol 3000, glycerin triacetate, iron oxide yellow (E172), iron oxide red (E172), iron oxide black (E172).

Indapen SR Dosage form

Modified release coated tablets.

Basic physical and chemical properties:

film-coated tablets, pale pink, round, biconvex.

Pharmacological group

Moderately active non-thiazide diuretics. Antihypertensive agent. ATX code С0ЗВ А11.

Indapen SR Pharmacological properties

Pharmacodynamics.

Indapamide is a diuretic drug. It belongs to the group of non-thiazide sulfonamide derivatives and contains an indole ring. In terms of pharmacological properties, it is close to thiazide diuretics. Like thiazide diuretics, it acts in the proximal part of the distal convoluted tubules of the nephron, where it causes an increased release of sodium and chloride and, to a lesser extent, potassium and magnesium, thus increasing the volume of urine excreted.

The antihypertensive efficacy of indapamide lasts for 24 hours. This effect is inherent in doses with a moderate diuretic effect.

The antihypertensive properties of indapamide are to improve the elasticity of the arteries and reduce the resistance of small arteries and the total peripheral resistance of the vessels.

Indapamide reduces left ventricular hypertrophy.

For thiazides and thiazide-like diuretics, a dose is established above which the therapeutic effect does not increase, but at the same time the likelihood of side effects increases. So, if the treatment was ineffective, you should not increase the dose of the drug.

Indapamide also does not affect the concentration of lipids (total cholesterol, cholesterol with low density lipids and triglycerides), does not affect glucose metabolism in patients with diabetes mellitus and arterial hypertension.

Indications

Essential arterial hypertension.

Contraindications

Hypersensitivity to indapamide and / or other components of the drug or to other sulfonamides.
Severe renal failure.
Hepatic encephalopathy or other severe liver dysfunction.
Hypokalemia.