Ingamist solution for injections 100 mg/ml. 3 ml. ampoules №10

$39.00

Manufacturer: Ukraine

Acute and chronic respiratory diseases accompanied by increased sputum formation.

Category:

Description

Ingamist Storage
active substance: acetylcysteine;

1 ml contains 100 mg of acetylcysteine;

Excipients: disodium edetate, sodium hydroxide, water for injections.

Ingamist Dosage form
Solution for injection.

Main physical and chemical properties: clear colorless liquid with a faint odor of sulfur.

After opening the ampoule, prolonged contact with air may cause a faint pink-purple tinge.

Ingamist Pharmacotherapeutic group
Mucolytic agent. ATX code R05C B01.

Pharmacological properties
Pharmacodynamics

Acetylcysteine ​​dilutes sputum. Even in the structure of acetylcysteine ​​sulfhydryl groups contributes to the rupture of disulfide bonds of acidic mucopolysaccharides of sputum, which leads to depolarization of mucoproteins and reduce the viscosity of mucus. The drug remains active in the presence of purulent sputum.

Acetylcysteine ​​has an antioxidant effect due to the presence of nucleophilic thiol SH-group, which easily gives off hydrogen, neutralizing oxidative radicals.

The protective mechanism of acetylcysteine ​​is based on the ability of its reactive sulfhydryl groups to bind free radicals.

Acetylcysteine ​​easily penetrates into the cell, deacetylated to L-cysteine, from which intracellular glutathione is synthesized.

Glutathione is a highly reactive tripeptide, a powerful antioxidant, cytoprotector that captures endogenous and exogenous free radicals and toxins. Acetylcysteine ​​prevents depletion and promotes the synthesis of intracellular glutathione, which is involved in the redox processes of cells, thus contributing to the detoxification of harmful substances.

Pharmacokinetics

With intravenous administration of 600 mg of acetylcysteine, the maximum concentration in blood plasma is 300 mmol / l, the half-life from blood plasma is 2 hours. The total clearance is 0.21 l / h / kg and the plateau volume is 0.34 l / kg. Acetylcysteine ​​penetrates into the intercellular space, is mainly distributed in the liver, kidneys, lungs, bronchial secretions. Acetylcysteine ​​and its metabolites are excreted mainly by the kidneys.

Indication
Acute and chronic respiratory diseases accompanied by increased sputum production.

Contraindication
Hypersensitivity to acetylcysteine ​​or to other components of the drug, peptic ulcer of the stomach and duodenum in the acute stage, hemoptysis, pulmonary hemorrhage.