Iodomarin tablets 100 mcg. №100

Description

Iodomarin 100 mcg Storage

active substance: 1 tablet contains potassium iodide 131 μg, which corresponds to iodide 100 μg;

Excipients: lactose monohydrate, magnesium carbonate basic lung, gelatin, sodium starch glycolate (type A), colloidal anhydrous silica, magnesium stearate.

Iodomarin 100 mcg Dosage form

Tablets.

Main physical and chemical properties: tablets with plane-parallel surfaces, with beveled edges and a notch for separation on one side; color of the tablet: at the release of the series – from white to almost white, and for the shelf life – from white to creamy white.

Iodomarin 100 mcg Pharmacotherapeutic group

Iodine preparations used in diseases of the thyroid gland.

ATX code H03C A.

Pharmacological properties

Pharmacodynamics

Iodine is a vital trace element that is part of the thyroid hormones – thyroxine (T4) and triiodothyronine (T3), which ensures its normal functioning.

When iodides enter the epithelial cells of the thyroid follicles under the influence of the enzyme iodide peroxidase, iodine is oxidized to form elemental iodine. The substance undergoes a substitution reaction with the aromatic cycle of tyrosine, resulting in the formation of tyronines: 3,5-iodine derivative (hormone thyroxine – T4) and 3-iodine derivative (hormone triiodothyronine T3). Tyronines form a complex with the protein thyroglobulin, which is deposited in the colloid of the thyroid follicle and stored in this state for several days and weeks. With iodine deficiency, this process is disrupted. Iodine, which enters the body in physiological quantities, prevents the development of endemic goiter associated with a lack of this element in food; normalizes the size of the thyroid gland in newborns, children and adult patients of young age; affects the ratio of T3 / T4, the level of TSH.

Pharmacokinetics

After oral administration, iodine is almost completely absorbed in the small intestine. Within 2 hours after absorption, it is distributed in the intercellular space; accumulates in the thyroid gland, kidneys, stomach, mammary and salivary glands. The volume of distribution in a healthy person averages 23 liters (38% of body weight). The concentration in blood plasma after the application of a standard dose is 10-50 ng / ml, and the content of iodine in breast milk, saliva, gastric juice is 30 times higher than the concentration in blood plasma. The thyroid gland contains ¾ (10-20 mg) of all iodine in the body. Iodine is excreted mainly in the urine, to a lesser extent in the lungs and feces. When the equilibrium concentration is reached, the amount of iodine excreted is proportional to the daily intake with food.

Clinical characteristics

Indication

Prevention of iodine deficiency, including during pregnancy or breastfeeding. Prevention of recurrence of iodine-deficient goiter after surgical removal, as well as after completion of complex treatment with thyroid hormone drugs.

Treatment of diffuse euthyroid goiter in children, including newborns and adults.

Contraindication

Hypersensitivity to iodine or to any of the other components of the drug. Manifest hyperthyroidism. The use of potassium iodide in doses exceeding 150 mcg of iodine per day in latent hyperthyroidism. Use of potassium iodide in doses from 300 to 1000 mcg of iodine per day in autonomic adenoma, focal and diffuse autonomic foci of the thyroid gland, except for preoperative iodine therapy to block the thyroid gland according to Plummer. Pulmonary tuberculosis. Hemorrhagic diathesis. Duhring’s herpetiform dermatitis (Duhring-Brock syndrome).