Ipamid coated tablets 0.0025 g. №30

$11.00

Manufacturer: Ukraine

Essential hypertension.

Category:

Description

Ipamid Composition
active substance: indapamide;
1 tablet contains indapamide 2.5 mg;
excipients: lactose monohydrate, microcrystalline cellulose, hypromellose (hydroxypropylmethylcellulose), copovidone, colloidal anhydrous silica, magnesium stearate;
shell: Opadry II Yellow film coating mixture: hydroxypropylmethylcellulose, lactose monohydrate, polyethylene glycol, triacetin, quinoline yellow (E 104), titanium dioxide (E 171), aluminum varnishes (indigo carmine (E 132), yellow measure FCF .
Ipamid Release form
10 tablets in a blister; 3 blisters in a pack.

Dosage form
Film-coated tablets.
Round tablets with a biconvex surface, coated with a yellow film.

Ipamid Active substance

Indapamide

Pharmacodynamics
Antihypertensive agent (diuretic, vasodilator). Pharmacologically similar to thiazide diuretics (impaired reabsorption of Na + in the cortical segment of the Henle loop). Increases urinary excretion of Na +, Cl- and to a lesser extent – K + and Mg2 +. Having the ability to selectively block the “slow” calcium channels, increases the elasticity of the walls of the arteries and reduces the total peripheral vascular resistance (ZPSO). Helps reduce left ventricular hypertrophy. Practically does not affect the content of lipids in plasma (TG, low-density lipoprotein, high-density lipoprotein); does not affect carbohydrate metabolism (including in patients with diabetes). Reduces the sensitivity of the vascular wall to norepinephrine and angiotensin II; stimulates the synthesis of prostaglandin E2.

The antihypertensive effect develops by the end of the first week, persists for 24 hours on a single dose.

Pharmacokinetics
Quickly and completely absorbed from the gastrointestinal tract; bioavailability is high (93%). Eating slightly slows the rate of absorption, but does not affect the amount of substance absorbed. Maximum concentration – 1-2 hours after oral administration. Equilibrium concentration is established after 7 days of regular intake. The half-life averages 18 hours, binding to plasma proteins is 79%. Also binds to elastin smooth muscle of the vascular wall. It has a high volume of distribution, passes through histohematological barriers (including placental), penetrates into breast milk.

Metabolized in the liver. The kidneys excrete 60-80% in the form of metabolites (unchanged excreted about 5%), through the intestine – 20%.

Indications
Arterial hypertension.

Contraindications
Hypersensitivity to indapamide and other components of the drug or other sulfonamides; severe renal failure; hepatic encephalopathy and severe hepatic impairment; hypokalemia.