Izoniazid tablets 0.2 №50

Description

Izoniazid  Composition
active substance: isoniazid;

1 tablet contains isoniazid (in terms of dry matter) 200 mg;

excipients: corn starch, crospovidone, calcium stearate.

Izoniazid  Dosage form
Pills.

Basic physical and chemical properties:

tablets of 200 mg tablets are round, white or almost white, with a flat surface, with beveled edges (beveled) and scored.

Izoniazid  Pharmacotherapeutic group
Anti-tuberculosis drugs. ATX code J04A C01.

Pharmacodynamics
Isoniazid has a high bacteriostatic activity against Mycobacterium tuberculosis, actively multiplies, less effective to bacteria at rest. Its mechanism of action is associated with the suppression of the synthesis of long-chain mycolic acids, which are components of the cell wall of mycobacteria. The drug inhibits the growth of mycobacteria in humans at a concentration of 0.03 μg / ml. The drug does not have a pronounced chemotherapeutic effect on other common pathogens of infectious diseases.

Pharmacokinetics
It is well absorbed from the digestive tract, easily penetrates the blood-brain barrier and manifests itself in various tissues and body fluids. After oral administration, the maximum concentration in the blood is reached after 1-4 hours, the tuberculostatic concentration in the blood after administration in a single dose is contained for 6-24 hours.

It is excreted mainly by the kidneys. According to the amount of active isoniazid excreted in the urine relative to the dose taken, patients are divided into “slow” and “fast” inactivators. The first category includes patients in whom up to 10% of isoniazid per day is excreted in the urine, in the second – more than 10% per day.

The half-life of isoniazid in blood plasma with rapid acetylation is 0.5-1.6 hours, with slow acetylation – 2-4 hours, with renal failure – 2-5 hours, with severe renal failure – 5-7 hours.

Indications
In combination with 3-4 other anti-tuberculosis drugs – for the treatment of active tuberculosis of all forms and localizations;
As monotherapy – for the treatment of latent tuberculosis infection and the prevention of tuberculosis in persons who have been or are in close contact with tuberculosis patients.
Contraindications
Hypersensitivity to isoniazid or other components of the drug;
Epilepsy, tendency to seizures;
Severe psychosis (including history);
Poliomyelitis (including previously transferred);
History of toxic hepatitis as a result of the use of isonicotinic acid hydrazine derivatives (ftivazide);
Acute hepatic and / or renal failure;
Severe atherosclerosis;
In doses more than 10 mg / kg of body weight in case of pulmonary heart failure of the III degree, arterial hypertension of II-III stages, ischemic heart disease, diseases of the nervous system, chronic renal failure, hepatitis during an exacerbation, cirrhosis of the liver, bronchial asthma, psoriasis, eczema in the acute phase, hypothyroidism, myxedema.
Interaction with other medicinal products and other forms of interaction
When isoniazid is prescribed to patients with slow inactivation of the drug, who are simultaneously receiving paraaminosalicylic acid, the tissue concentration of the drug may be increased, resulting in an increased risk of side effects.