Izoprinozin tablets 500 mg. №30

Description

IZOPRINOZIN №30 DOSAGE FORM:
oblong tablets, white, odorless or with

low amine odor, with a division line on one side

composition: 1 tablet contains 500 mg of inosiplex (inosine pranobex)

Excipients: magnesium stearate, povidone, starch, mannitol.

IZOPRINOZIN №30 RELEASE FORM.
Pills.

IZOPRINOZIN №30 PHARMACOTHERAPEUTIC GROUP.
Antiviral drugs for systemic use. ATC code J05A X05.

PHARMACOLOGICAL PROPERTIES.
Pharmacodynamics. isoprinosine is an antiviral agent with immunomodulatory properties. Acts on the immune system and cellular immune response, increases the body’s own defenses against viral infections and at the same time suppresses the multiplication of viruses.

Pharmacokinetics. After oral administration in a dose of 1.5 g, the maximum concentration of inosiplex in blood plasma is reached after 1 hour and is 600 μg / ml. In the body, inosiplex is metabolized to form uric acid. The half-life is 50 minutes. The half-life of the second component of the complex is 3-4 hours. It is excreted by the kidneys in the form of metabolites.

INDICATIONS FOR USE.
Viral infections in patients with normal immune status and in immunodeficient conditions, including diseases caused by Herpes simplex viruses types 1 and 2, Varicella zoster (including chickenpox), measles viruses, mumps, cytomegalovirus, Epstein-Barr virus, acute viral bronchitis and chronic viral hepatitis B and C, diseases caused by the human papillomavirus, subacute sclerosing panencephalitis, chronic infectious diseases of the urinary and respiratory systems, stressful situations, the period of convalescence in postoperative patients and people who have undergone severe diseases, immunodeficiency states, advanced age of radiation therapy.

Application. The drug is administered orally Daily dose for adults

is 50 mg / kg in 3 – 4 doses, for children – 50 – 100 mg / kg in 3 – 4 doses. Treatment course 5 –

10 days, in severe cases – up to 15 days, long-term use is possible.

For diseases caused by Herpes Simplex viruses types 1 and 2, treatment continues until

disappearance of symptoms of the disease and another 2 days.

With subacute sclerosing panencephalitis, the daily dose for adults and children is 50 –

100 mg / kg in 6 divided doses.

In acute viral encephalitis, the daily dose for adults and children is 50 – 100 mg / kg

in 4 – 6 doses for 7 – 10 days. Then there comes a break – 8 days, then a second one is carried out.

course 7 – 10 days. If necessary, the dose and duration of the continuous course can be increased, but an 8-day break should be observed after 7-10 days of treatment.

For genital warts (in combination therapy with a CO2 laser) – 50 mg / kg in 3 doses for 5 days, then with a three-time repetition of the specified course at intervals of 1 month.

SIDE EFFECT.
The only side effect that occurs most often is an increase in urinary

acid in serum and urine, which normalizes while on the go or through

a few days after the end of treatment.

Rare side effects.

From the nervous system and sensory organs: dizziness, weakness, headache.

From the digestive tract: at the beginning of treatment, dyspeptic symptoms, rarely –

increased activity of hepatic transaminases.

In exceptional cases, joint pain occurs.

CONTRAINDICATIONS
Hypersensitivity to the components of the drug. Gout, urolithiasis, renal failure, cardiac arrhythmias, pregnancy, lactation.

OVERDOSE.
Unknown.