Izoprinozin tablets 500 mg. №50

Description

Izoprinozin Composition
active substance: inosine pranobex;

1 tablet contains 500 mg of inosine pranobex;

excipients: mannitol (E 421), wheat starch, povidone, magnesium stearate.

Izoprinozin Dosage form
Pills.

Basic physical and chemical properties: oblong tablets of white or almost white color with a break line on one side. Odorless or slightly odorless of amines.

Izoprinozin Pharmacotherapeutic group
Antimicrobial agents for systemic use. Antiviral agents for systemic use. Direct-acting antiviral agents.

ATX code J05A X05.

Pharmacodynamics
Isoprinosine is an antiviral agent with immunomodulatory properties. The drug normalizes (in individual norms) the deficiency or dysfunction of cellular immunity, inducing the maturation and differentiation of T-lymphocytes and T1-helpers, potentiating the induction of lymphoproliferative responses in mitogen or antigenic cells. Isoprinosine simulates the cytotoxicity of T-lymphocytes and natural killer cells, the function of T8-suppressors and T4-helpers, and also increases the amount of immunoglobulin G and surface compliment markers. Isoprinosine increases the synthesis of interleukin-1 (IL-1) and the synthesis of interleukin-2 (IL-2), regulates the expression of IL-2 receptors. Isoprinosine significantly increases the secretion of endogenous interferon gamma and decreases the production of interleukin-4 in the body. Isoprinosine enhances the action of neutrophils, chemotaxis and phagocytosis of monocytes and macrophages. Isoprinosine inhibits viral synthesis by incorporating inosine-orotic acid into the polyribosomes of a virus-infected cell and inhibits the attachment of adenylic acid to viral i-RNA.

Pharmacokinetics
After oral administration in a dose of 1.5 g, the maximum concentration of inosine pranobex in blood plasma is reached after 1 hour and is 600 μg / ml. In the body of inosine, pranobex is metabolized in the liver to form uric acid. The half-life of 4 (acetylamino) benzoate is 50 minutes, 1 (dimethylamino) -2-propanol is 3.5 hours. It is excreted by the kidneys in the form of metabolites.

Izoprinozin Indications
Isoprinosine is indicated for the treatment of a decrease or dysfunction of cell-mediated immunity and clinical symptoms associated with such diseases:

viral respiratory infections, primary and secondary and immunosuppressive conditions; infections caused by herpes viruses: herpes simplex virus types 1 and 2, a virus
chickenpox; infections caused by cytomegalovirus and Epstein-Barr virus;
genital warts (genital warts) – external lesions (with the exception of perianal areas and areas inside the anal canal) – as monotherapy or as an auxiliary therapy as part of local or surgical treatment;
papillomavirus infection of the skin and mucous membranes, vulva and vagina (subclinical), or cervix;
viral hepatitis;
severe or difficult measles;
subacute sclerosing panencephalitis.

Contraindications
Hypersensitivity to the active substance or to any excipient of the drug, exacerbation of gout, hyperuricemia.

Interaction with other medicinal products and other forms of interaction
Caution should be given to the drug with xanthine oxidase inhibitors (for example, allopurinol) or drugs that promote the excretion of uric acid, including diuretics, in particular with thiazide diuretics (such as hydrochlorothiazide, chlorthalidone, indapamide) or loop diuretics (for example, furosemide, torasemide, thorasemide, thorasemide, ethacrynic acid).

Isoprinosine can be used after, but not simultaneously with, immunosuppressants, since a pharmacokinetic effect on the desired therapeutic effects is possible.

With simultaneous use with zidovudine (azidothymidine), the formation of zidovudine nucleotide is increased by many mechanisms, in particular due to an increase in the bioavailability of zidovudine in blood plasma and an increase in intracellular phosphorylation in human blood monocytes. The consequence of this is an increase in the action of zidovudine.