Description

Janumet (Metformin + Sitagliptin) Coated Tablets 50 mg/1000 mg. №56

Composition

Each coated tablet contains 50 mg of metformin and 1000 mg of sitagliptin.

Mechanism of Action

Janumet works by combining the mechanisms of metformin, which reduces glucose production in the liver and improves insulin sensitivity, with sitagliptin, which increases insulin release in response to meals. This dual action helps to regulate blood sugar levels throughout the day.

Pharmacological Properties

Metformin and sitagliptin in Janumet act synergistically to control blood glucose levels in patients with type 2 diabetes mellitus. Metformin decreases hepatic glucose production and enhances peripheral glucose uptake, while sitagliptin increases incretin levels, resulting in improved glycemic control.

Indications for Use

Janumet is indicated for the treatment of type 2 diabetes mellitus. It is recommended for patients who require additional glycemic control beyond what metformin or sitagliptin alone can provide.

Contraindications

Do not use Janumet if you have a history of allergic reactions to metformin or sitagliptin. It is contraindicated in patients with severe renal impairment, acute or chronic metabolic acidosis, or diabetic ketoacidosis.

Side Effects

Common side effects of Janumet may include gastrointestinal symptoms such as nausea, vomiting, diarrhea, and abdominal discomfort. Rare but serious side effects may include lactic acidosis, pancreatitis, and allergic reactions.

Usage Instructions

The recommended dosage is one tablet of Janumet 50 mg/1000 mg twice daily with meals. Follow the instructions provided by your healthcare provider and do not adjust the dosage without medical guidance.

Benefits Compared to Analogues

Janumet offers the advantage of dual therapy with metformin and sitagliptin, providing comprehensive glycemic control through complementary mechanisms. This combination has been shown to be more effective than metformin alone in managing blood sugar levels.

Suitable Patient Groups

Janumet is suitable for adult patients with type 2 diabetes mellitus who require additional treatment to achieve glycemic targets. It is not recommended for use in children, and caution should be exercised in elderly patients or those with renal impairment.

Storage and Shelf Life

Store Janumet in a cool, dry place away from moisture and heat. Keep the tablets in their original packaging to protect them from light. Check the expiration date on the packaging and do not use the product after it has expired.

Packaging Description

Janumet is available in blister packs containing 56 coated tablets. Each tablet is imprinted with the product name and strength for easy identification.

Clinical Evidence and Proven Effectiveness

Studies have demonstrated the efficacy of Janumet in lowering blood glucose levels and improving glycemic control in patients with type 2 diabetes. Research published in the Journal of Clinical Endocrinology & Metabolism has shown the superior effectiveness of Janumet compared to metformin monotherapy.

Additional Information

Regular monitoring of renal function is essential during Janumet therapy due to the potential impact of metformin and sitagliptin on kidney function. Patients should promptly report any changes in health status or adverse effects to their healthcare provider for proper management.