Description

Janumet (metformin + sitagliptin) Coated Tablets 50 mg/1000 mg. №56

Ingredients

Each coated tablet contains 50 mg of metformin and 1000 mg of sitagliptin.

Dosage

The recommended dosage is one tablet twice daily with meals.

Indications

Janumet is indicated for the treatment of type 2 diabetes mellitus. It helps to control blood sugar levels in patients who are unable to achieve sufficient glycemic control with metformin alone or in combination with sitagliptin.

Contraindications

Do not use Janumet if you have a history of allergic reactions to metformin or sitagliptin. It is also contraindicated in patients with severe renal impairment, acute or chronic metabolic acidosis, or diabetic ketoacidosis.

Directions

Take Janumet exactly as prescribed by your healthcare provider. Follow all instructions on the prescription label and do not take more or less of the medication than recommended.

Scientific Evidence

Studies have shown that the combination of metformin and sitagliptin in Janumet is effective in lowering blood glucose levels and improving glycemic control in patients with type 2 diabetes. Research published in the Journal of Clinical Endocrinology & Metabolism demonstrated the superior efficacy of Janumet compared to metformin alone.

Additional Information

It is important to monitor renal function regularly while taking Janumet, as both metformin and sitagliptin can affect kidney function. Inform your healthcare provider of any changes in your health status or if you experience any side effects while taking Janumet.

Janumet works by combining the mechanisms of metformin, which reduces glucose production in the liver and improves insulin sensitivity, with sitagliptin, which increases insulin release in response to meals. This dual action helps to regulate blood sugar levels throughout the day.

Clinical trials have shown that Janumet is well-tolerated and has a favorable safety profile in patients with type 2 diabetes. Long-term studies have demonstrated the sustained efficacy of Janumet in maintaining glycemic control and reducing the risk of diabetic complications.