Description

Janumet (metformin + sitagliptin) Coated Tablets 50 mg/500 mg. №56

Ingredients:

Each tablet contains 50 mg of sitagliptin and 500 mg of metformin.

Dosage:

The usual dose is one tablet twice daily with meals.

Indications:

Janumet is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Contraindications:

Do not use Janumet in patients with severe renal impairment, acute or chronic metabolic acidosis, or hypersensitivity to metformin or sitagliptin.

Directions:

Swallow the tablets whole with a glass of water. Do not crush or chew the tablets.

Scientific Evidence:

Studies have shown that the combination of metformin and sitagliptin in Janumet leads to improved glycemic control by reducing fasting and postprandial plasma glucose levels. The dual mechanism of action of these two drugs targets insulin resistance and enhances insulin secretion, making it a potent option for managing type 2 diabetes.

Clinical trials have demonstrated the efficacy of Janumet in lowering HbA1c levels and improving beta-cell function. Research published in the Journal of Clinical Endocrinology & Metabolism highlighted the significant reduction in HbA1c levels with the use of Janumet compared to metformin alone.

Additional Information:

• Janumet may cause gastrointestinal side effects such as nausea, vomiting, or diarrhea. These symptoms usually improve with continued use.
• Regular monitoring of renal function is recommended while taking Janumet to prevent lactic acidosis.