Description
Ketoconazol (Ketoconazole) 400 mg Tablets
Composition
Each tablet of Ketoconazol 400 mg contains the active ingredient Ketoconazole. Ketoconazole is a broad-spectrum antifungal medication used to treat a variety of fungal infections.
Mechanism of Action
Ketoconazole exerts its antifungal effect by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes. This disruption leads to fungistatic or fungicidal activity against various pathogenic fungi.
Pharmacological Properties
Ketoconazole demonstrates antifungal activity against a wide spectrum of fungi, including Candida species and dermatophytes. Following oral administration, it is well-absorbed and distributed throughout the body, achieving therapeutic concentrations in skin, nails, and mucous membranes.
Indications for Use
Ketoconazol 400 mg is indicated for the treatment of systemic fungal infections, such as candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Contraindications
- Patients with a known hypersensitivity to ketoconazole or any other ingredients in the formulation should avoid this medication.
- Individuals with acute or chronic liver disease should refrain from using Ketoconazol 400 mg tablets.
Side Effects
Common side effects of Ketoconazol 400 mg may include nausea, vomiting, abdominal pain, rash, and liver function abnormalities. Rare but severe side effects may involve hepatotoxicity and adrenal insufficiency.
Usage Instructions
Ketoconazol 400 mg should be taken orally with a meal to enhance absorption. Swallow the tablets whole with a full glass of water. Do not chew or crush the tablets to preserve the controlled-release formulation.
Benefits Compared to Analogues
Ketoconazol 400 mg stands out for its broad-spectrum antifungal activity and well-established safety profile. Its efficacy in managing various fungal infections positions it as a preferred choice over some alternative antifungal agents.
Suitable Patient Groups
Ketoconazol 400 mg is appropriate for use in adult patients with systemic fungal infections. Dosage adjustments may be required for elderly individuals or those with renal impairment. The safety and efficacy of this medication in pediatric populations have not been extensively studied.
Storage and Shelf Life
Store Ketoconazol 400 mg tablets at room temperature, away from moisture and heat. Verify the expiration date on the packaging and refrain from using the medication if expired. Keep the tablets out of children’s reach.
Packaging Description
Ketoconazol 400 mg tablets are typically packaged in blister packs containing 10 tablets each. The packaging should provide details about the manufacturer, dosage instructions, and potential side effects. Ensure that the packaging is undamaged before using the tablets.
