Description
Ksilo-Mefa (Xylometazoline Hydrochloride) Nasal Spray 0.5 mg/ml. 10 ml
Ingredients
Active ingredient: Xylometazoline hydrochloride. Other ingredients: benzalkonium chloride, sodium dihydrogen phosphate dihydrate, disodium phosphate dodecahydrate, and purified water.
Mechanism of Action
Xylometazoline hydrochloride, a selective alpha-1 adrenergic receptor agonist, constricts blood vessels in the nasal passages, reducing swelling and congestion.
Pharmacological Properties
The vasoconstrictive action of xylometazoline leads to decreased nasal congestion by reducing blood flow and swelling in the nasal mucosa.
Indications
Ksilo-Mefa Nasal Spray is indicated for the relief of nasal congestion associated with allergic rhinitis, sinusitis, and colds.
Contraindications
Do not use if hypersensitive to xylometazoline or any other ingredients in the formulation. Prolonged use should be avoided.
Side Effects
Common side effects may include nasal dryness, irritation, or sneezing. Rebound congestion can occur with prolonged use.
Usage Instructions
- Blow nose gently before administration.
- Administer 1-2 sprays into each nostril 2-3 times a day.
- Avoid deep inhalation during application.
- Clean the nozzle after each use and securely close the cap.
Benefits Compared to Analogues
Xylometazoline provides rapid relief with minimal systemic absorption, making it a preferred choice for nasal congestion.
Suitable Patient Groups
Safe for adults and children over 12 years. Consult a healthcare professional for children under 12.
Storage and Shelf Life
Store in a cool, dry place away from direct sunlight. Check the packaging for the expiry date.
Packaging Description
Ksilo-Mefa Nasal Spray is available in a 10 ml container for easy application.
Scientific Evidence
Xylometazoline has shown rapid relief from nasal congestion with minimal systemic effects, making it a preferred decongestant.
Additional Information
Prolonged use may lead to rebound congestion. Limit use to 3-5 days to avoid this effect.
Clinical Trials and Comparative Effectiveness
Clinical trials confirm the efficacy of xylometazoline in providing rapid relief compared to placebo. Comparative studies show similar effectiveness to other decongestants with lower systemic side effects.
