Description

Ksilo-Mefa (xylometazoline hydrochloride) Nasal Spray 0.5 mg/ml. 10 ml

Ingredients

Active ingredient: Xylometazoline hydrochloride. Other ingredients: benzalkonium chloride, sodium dihydrogen phosphate dihydrate, disodium phosphate dodecahydrate, and purified water.

Dosage

Adults and children over 12 years: 1-2 sprays into each nostril 2-3 times a day. Do not exceed 3 applications per nostril daily.

Indications

Ksilo-Mefa Nasal Spray is indicated for the relief of nasal congestion associated with allergic rhinitis, sinusitis, and colds.

Contraindications

Do not use in case of hypersensitivity to xylometazoline or any other ingredients in the formulation. Avoid prolonged use.

Directions

1. Blow your nose gently to clear the nostrils before using the spray.
2. Administer the prescribed number of sprays into each nostril as directed.
3. Avoid inhaling deeply during administration.
4. Clean the nozzle after each use and close the cap securely.

Scientific Evidence

Xylometazoline hydrochloride, the active ingredient in Ksilo-Mefa Nasal Spray, is a selective alpha-1 adrenergic receptor agonist. It works by constricting the blood vessels in the nasal passages, reducing swelling and congestion. Studies have shown that xylometazoline provides rapid relief from nasal congestion with minimal systemic absorption, making it a preferred choice for nasal decongestion.

Additional Information

It is important to note that prolonged use of nasal decongestants like xylometazoline can lead to rebound congestion, where the nasal passages become more congested when the medication is stopped. To prevent this, it is recommended to use the spray for a maximum of 3-5 days. If symptoms persist, consult a healthcare professional.

Clinical Trials and Comparative Effectiveness

Clinical trials have demonstrated the efficacy of xylometazoline in providing rapid relief from nasal congestion compared to placebo. Additionally, comparative studies have shown that xylometazoline nasal spray has similar effectiveness to other decongestants but with a lower risk of systemic side effects due to its localized action.

Overall, Ksilo-Mefa Nasal Spray offers effective relief from nasal congestion with a well-established safety profile supported by scientific evidence and clinical trials.