Description

L-Tiroxine (Levothyroxine Sodium) 75 Tablets 75 mcg. №50

Ingredients

Active ingredient: Levothyroxine sodium.
Other ingredients: Microcrystalline cellulose, croscarmellose sodium, magnesium stearate, and colloidal silicon dioxide.

Dosage

Adult Dosage: The usual starting dose is 25-50 mcg per day, with gradual increments of 25 mcg every 2-4 weeks based on clinical response and laboratory parameters.

Indications

L-Tiroxine (Levothyroxine Sodium) 75 mcg tablets are indicated for the treatment of hypothyroidism, including myxedema coma and cretinism.

Contraindications

Contraindications include: untreated thyrotoxicosis, acute myocardial infarction, and hypersensitivity to any component of the product.

Directions

Directions for use: Take this medication orally as directed by your healthcare provider, usually once daily on an empty stomach, 30 minutes to 1 hour before breakfast.

Scientific Evidence

Levothyroxine is a synthetic form of thyroxine, a hormone produced by the thyroid gland. Studies have shown that levothyroxine is effective in improving symptoms of hypothyroidism and restoring normal thyroid hormone levels in the body. Research published in the Journal of Clinical Endocrinology & Metabolism has demonstrated the efficacy of levothyroxine in reducing symptoms such as fatigue, weight gain, and depression in patients with hypothyroidism.

Additional Information

It is important to monitor thyroid function tests regularly while taking levothyroxine to ensure optimal dosing and effectiveness. Inform your healthcare provider about any other medications or supplements you are taking, as they may interact with levothyroxine. Do not stop taking this medication without consulting your doctor, as sudden discontinuation can lead to adverse effects.

Pharmacological Effects

Levothyroxine acts as a synthetic replacement for the thyroid hormone thyroxine. It functions by increasing the levels of thyroid hormone in the body, which helps regulate metabolism, energy levels, and growth. By mimicking the action of the natural hormone, levothyroxine effectively treats hypothyroidism and its associated symptoms.

Clinical Trials and Comparative Effectiveness

Clinical trials have shown that levothyroxine is a safe and effective treatment for hypothyroidism. A study published in JAMA Internal Medicine compared the effectiveness of different thyroid hormone replacement therapies and found levothyroxine to be superior in improving symptoms and restoring thyroid function. Compared to similar drugs, levothyroxine has been widely used for decades and is considered the gold standard in hypothyroidism treatment.