Lamicon cream 1% 15 g.

Description

Lamicon cream Composition
active substance: terbinafine;

1 g of cream contains terbinafine hydrochloride in terms of 100% anhydrous substance – 0.01 g;

excipients: phenylethyl alcohol, white soft paraffin, mineral oil, cetostearyl alcohol, polyethylene glycol (macrogol) 20 cetostearyl ether, propylene glycol, poloxamer 407, sodium hydroxide, purified water.

Lamicon cream Dosage form
Cream.

Basic physical and chemical properties: cream of white or almost white color with a specific odor.

Lamicon cream Pharmacotherapeutic group
Antifungal drugs for topical use.

ATX code D01A E15.

Pharmacological properties

Pharmacodynamics

Terbinafine is an alilamine and has a broad spectrum of antifungal activity. Terbinafine in low concentrations has a fungicidal effect against dermatophytes, molds and some dimorphic fungi. Activity against yeast fungi, depending on their type, can be fungicidal or fungistatic. The drug has a long-term effect, which makes it possible to achieve an effect in a short period of treatment.

Terbinafine specifically inhibits the early stage of sterol biosynthesis in the fungal cell membrane. This leads to a deficiency of ergosterol and to intracellular accumulation of squalene, which leads to the death of the fungal cell. Terbinafine acts by inhibiting the enzyme squalene epoxidase in the cell membrane of the fungus. This enzyme does not belong to the cytochrome P450 system. Terbinafine does not affect the metabolism of hormones or other drugs.

Pharmacokinetics

When applied externally, less than 5% of the dose is absorbed, therefore, the absorption of terbinafine into the systemic circulation is negligible.

Terbinafine quickly begins to act, is effective with short-term treatment (7 days). After 7 days of treatment with the drug Lamicon, cream, terbinafine concentrations exceeding those required for fungicidal action are present in the stratum corneum of the epidermis for at least 7 days after stopping treatment.

Indications
Fungal infections of the skin caused by dermatophytes such as Trichophyton (eg T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum, eg dermatophytosis of the feet; inguinal dermatophytosis (“jockey’s itch”); dermatophytosis of the trunk (ringworm); candidiasis of the skin caused by fungi of the genus Candida, usually Candida albicans; versicolor versicolor (Pityriasis versicolor) caused by Pityrosporum orbiculare (also known as Malassezia furfur).

Lamicon cream Contraindications
Hypersensitivity to terbinafine or to any of the components of the drug.

Interaction with other medicinal products and other types of interactions
Unknown.

Application features
The cream is for external use only. Contact of the cream with the eyes should be avoided, as the medication may irritate them. In case of accidental contact of the cream in the eyes, they must be thoroughly rinsed with running water. Lamicon, cream, contains cetostearyl alcohol, which can cause local skin irritation (eg, contact dermatitis).