$24.00
Manufacturer: Ukraine
Fungal skin infections caused by dermatophytes such as Trichophyton (e.g., T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis I Epidermophyton floccosum, for example, foot dermatophytosis; inguinal dermatophytosis (“jockey’s itch”); trunk dermatophytosis (“ringworm”); skin candidiasis caused by fungi of the genus Candida, usually Candida albicans; multicolored lichen (Pityriasis versicolor) caused by Pityrosporum orbiculare (also known as Malassezia furfur).
Description
Lamicon tablets Storage
active substance: terbinafine;
1 tablet contains terbinafine hydrochloride 281 mg (0.281 g) in terms of terbinafine 100% anhydrous substance 250 mg (0.250 g);
Excipients: microcrystalline cellulose, corn starch, colloidal anhydrous silica, sodium starch glycolate (type A), hydroxypropylmethylcellulose, magnesium stearate.
Lamicon tablets Dosage form
Tablets.
Main physical and chemical properties: tablets white or almost white, or with a yellowish tinge, round shape with a flat surface, chamfer and dash.
Lamicon tablets Pharmacotherapeutic group
Antifungal drugs for use in dermatology. Antifungal drugs for systemic use. Terbinafine. ATX code D01B A02.
Pharmacological properties
Pharmacodynamics
Terbinafine is an allylamine that has a broad spectrum of antifungal activity against skin, hair and nail infections caused by dermatophytes such as Trichophyton (eg, T. rubrum, T. mentagrophytes, T. verrucosum, T. tonsurans, T. violaceum), Microsporum ( for example, Microsporum canis), Epidermophyton floccosum and yeast fungi of the genus Candida (eg Candida albicans) and Pityrosporum. At low concentrations, terbinafine has a fungicidal effect on dermatophytes, molds and some dimorphic fungi. Activity against yeast fungi can be fungicidal or fungistatic, depending on their species.
Terbinafine specifically promotes the early stage of sterol biosynthesis in the fungal cell. The action of terbinafine is carried out by inhibiting the enzyme squalene epoxidase in the cell membrane of the fungus. This leads to ergosterol deficiency and intracellular accumulation of squalene, which causes fungal cell death. This enzyme does not belong to the cytochrome P450 system.
Indication
Fungal infections of the skin and nails caused by Trichophyton (eg, T. rubrum, T. mentagrophytes, T. verrucosum, T. violaceum), Microsporum canis and Epidermophyton floccosum.
1. Ringworm (trichophytia of smooth skin, trichophytia of the perineum and dermatophytia of the feet), when the location of the lesion, the severity or prevalence of the infection determine the appropriateness of oral therapy.
2. Onychomycosis.
Lamicon tablets Contraindication
Acute or chronic liver disease.
Hypersensitivity to terbinafine or to any of the excipients.
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