Lamitril tablets 100 mg. №60

Description

Lamitril Composition
active substance: lamotrigine

1 tablet contains lamotrigine 100 mg;

excipients: microcrystalline cellulose, lactose, sodium starch (type A), povidone, magnesium stearate, sunset yellow dye FCF (E 110).

Lamitril Dosage form
Pills.

Basic physical and chemical properties:

Tablets 100 mg tablets of light pink color (small orange blotches are allowed) in the form of a shield with an imprint “P 100” on one side and with a notch on the other.

Pharmacotherapeutic group
Antiepileptic drugs. Lamotrigine. ATX code N03A X09.

Pharmacodynamics
Lamotrigine is an anticonvulsant drug, the mechanism of action of which is associated with the blocking of voltage-dependent sodium channels of the presynaptic membranes of neurons in the phase of slow inactivation and inhibition of the excessive release of glutamate (an amino acid that plays a significant role in the development of an epileptic seizure).

Pharmacokinetics
After administration, the drug is rapidly and completely absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached after 2.5 hours.

Lamotrigine is actively metabolized, the main metabolite is N-glucuronide. The average elimination half-life in adults is 29 hours. Lamitril has a linear pharmacological profile. It is excreted mainly in the form of metabolites and partially unchanged, mainly in the urine. In children, the half-life is shorter than in adults.

Special patient groups

Children

The clearance, depending on body weight, is higher in children than in adults, with high rates in children under 5 years of age. The half-life of lamotrigine in children is usually shorter than in adults, with an average of about 7 hours when used concomitantly with enzyme inducers such as carbamazepine and phenytoin, and an increase in the mean by 45 to 50 hours when used exclusively with valproate.

Lamitril Indications
Epilepsy.

Adults and children over the age of 13

Monotherapy and adjunctive therapy for epilepsy, in particular partial and generalized seizures, including tonic-clonic seizures.

Seizures associated with Lennox-Gastaut syndrome. Lamitril is prescribed as an adjunctive therapy, but in Lennox-Gastaut syndrome, it can be prescribed as an initial antiepileptic drug (PEP).

Children aged 2 to 12

For adjunctive therapy of epilepsy, in particular partial and generalized seizures, including tonic-clonic seizures, as well as seizures associated with Lennox-Gastaut syndrome.

Monotherapy for typical absences.

Bipolar Disorder (Adults)

For the prevention of depressive conditions in patients with bipolar I disorder who mainly suffer from depressive conditions.

Lamitril is not indicated for the emergency treatment of manic or depressive episodes.

Lamitril Contraindications
Lamitril is contraindicated in patients with hypersensitivity to lamotrigine or any other component of the drug.