$30.00
Manufacturer: Ukraine
Epilepsy. Adults and children from 13 years old. Additional therapy or monotherapy for partial and generalized epilepsy seizures, including tonic-clonic seizures. Attacks associated with Lennox-Gastaut syndrome. The drug Lamotrin is prescribed as an additional therapy, but in Lennox-Gastaut syndrome, it can be intended as an initial antiepileptic drug (PEP). Children from 2 to 12 years old. Additional therapy for partial and generalized epilepsy seizures, including tonic-clonic seizures and seizures associated with Lennox-Gastaut syndrome. Monotherapy of typical absence seizures.
Description
Lamotrin-100 Composition
active substance: lamotrigine;
1 tablet contains lamotrigine 100 mg;
excipients: microcrystalline cellulose, colloidal silicon dioxide, povidone, sodium starch (type A), lactose, magnesium stearate.
Lamotrin-100 Dosage form
Pills.
Basic physical and chemical properties: tablets of white or almost white color, round, beveled, with a notch.
Lamotrin-100 Pharmacotherapeutic group
Antiepileptic drugs. Lamotrigine. ATX code N03A X09.
Pharmacodynamics
Lamotrigine, a derivative of phenyltriazine, is an antiepileptic agent, the mechanism of action of which is associated with the blockade of voltage-dependent sodium channels of the presynaptic membranes of neurons in the phase of slow inactivation and inhibition of the excessive release of excitatory neurotransmitters, primarily glutamate (an amino acid that plays a significant role in the development of epileptic seizures).
Pharmacokinetics
After oral administration, the drug is rapidly and completely absorbed in the digestive tract. The maximum concentration in blood plasma is reached after 2.5 hours.
Lamotrigine is extensively metabolized, with N-glucuronide being the main metabolite.
In adults, the half-life is 29 hours. Lamotrigine has a linear pharmacological profile. In children, the half-life is shorter than in adults. It is excreted mainly in the form of metabolites and partially unchanged, mainly in the urine. In children, the half-life is shorter than in adults.
Indications
Epilepsy.
Adults and children over the age of 13: monotherapy and adjunctive therapy for partial and generalized seizures of epilepsy, including tonic-clonic seizures, as well as seizures associated with Lennox-Gastaut syndrome. The drug Lamotrin is prescribed as an adjunct therapy, but in Lennox-Gastaut syndrome, it can be prescribed as the initial antiepileptic drug (PEP).
Children aged 2 to 12 years are additional therapy for epilepsy, in particular for partial and generalized seizures, including tonic-clonic seizures, as well as seizures associated with Lennox-Gastaut syndrome.
Monotherapy for typical absences.
Bipolar disorder in adults.
Adults (from 18 years old).
For the prevention of depressive conditions in patients with bipolar I disorder who mainly suffer from depressive conditions.
Lamotrigine is not indicated for the emergency treatment of manic or depressive episodes.
Lamotrin-100 Contraindications
Hypersensitivity to lamotrigine or other components of the drug.
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