Leflocin solution for infusions 5 mg/ml. 100 ml. vial

Description

LEFLOCIN SOLUTION COMPOSITION
active substance: 1 ml of levofloxacin hemihydrate in terms of 100% substance 5 mg
excipients: sodium chloride, sodium edetate, water for injection.

LEFLOCIN SOLUTION DOSAGE FORM
Solution for infusion.

LEFLOCIN SOLUTION PHARMACOLOGICAL GROUP
Antibacterial agents of the quinolone group. Fluoroquinolones. Levofloxacin. ATC code J01M A12.

LEFLOCIN SOLUTION INDICATIONS
Leflocine for administration is prescribed in the treatment of bacterial inflammatory processes in adults, if they are caused by bacteria sensitive to levofloxacin: pneumonia, complicated urinary tract infections (including pyelonephritis), infections of the skin and soft tissues, chronic bacterial prostatitis.

CONTRAINDICATIONS
Hypersensitivity to levofloxacin or other quinolones, epilepsy, complaints of side reactions from the tendons after prior use of quinolones.

DOSAGE AND APPLICATION
Leflocin for intravenous administration should be applied immediately (within 3:00) after the rubber stopper is perforated. No light protection required during infusion.

Under room lighting, solution for intravenous administration can be stored for no more than 3 days without protection from light.

Given the biological equivalence of oral and parenteral forms, the same dosage is possible.

CHILDREN
The use of the drug Leflocin is contraindicated in children and adolescents under the age of 18 years, since damage to the articular cartilage is possible.

FEATURES OF APPLICATION
In very severe pneumococcal pneumonia, Leflocin may not provide the optimal therapeutic effect.

Hospital infections with P. aeruginosa may require combination therapy.

Duration of administration.

The recommended duration of administration is at least 60 minutes for 500 mg of Leflocin solution for infusion. Regarding ofloxacin, it is known that tachycardia and a temporary increase in blood pressure may occur during infusion. In rare cases, a sharp drop in blood pressure, circulatory collapse, can be observed as a consequence. If a marked decrease in blood pressure is observed with the administration of levofloxacin (the l isomer of ofloxacin), the administration should be stopped immediately.

PHARMACOLOGICAL PROPERTIES
Pharmacodynamics. Levofloxacin is a synthetic antibacterial drug from the group of fluoroquinolones and is the S-enantiomer of the racemic mixture of the drug ofloxacin.

MECHANISM OF ACTION

As an antibacterial drug from the group of fluoroquinolones, levofloxacin acts on the DNA-DNA gyrase complex and topoisomerase IV.