Description

Legalon-70 Storage
active substance: dry extract of the fruits of milk thistle (Silybum marianum);

1 capsule contains 86.5–93.3 mg of dry extract from the fruits of milk thistle (Silybum marianum) [36-44: 1], which corresponds to 70 mg of silymarin (DNPH), or 54.1 mg of silymarin (HPLC / DAB) in transfer to silibinin (solvent – ethyl acetate);

Excipients: polysorbate 80, povidone, mannitol E 421, sodium starch glycolate (type A), magnesium stearate, iron oxide red E 172, iron oxide black E 172, titanium dioxide E 171, gelatin, sodium lauryl sulfate.

Legalon-70 Dosage form
Capsules.

Main physical and chemical properties: brown hard gelatin capsule size 2, containing yellow powder.

Legalon-70 Pharmacotherapeutic group
Drugs used in liver disease, lipotropic substances. Hepatotropic drugs.

ATX code A05B A03.

Legalon-70 Pharmacological properties
Pharmacodynamics.

The ability of silymarin to bind free radicals provides its antioxidant activity. Thus, the pathophysiological process of lipid peroxidation, which is responsible for the destruction of cell membranes, is interrupted or prevented. In damaged hepatocytes, silymarin stimulates protein synthesis and normalizes phospholipid metabolism, resulting in silymarin stabilizing cell membranes and limiting or preventing the loss of soluble components (including transaminases) of liver cells. Silymarin inhibits the penetration into the cell of some hepatotoxic substances (poison toadstool). Silymarin enhances protein synthesis due to specific stimulation of RNA polymerase A, an enzyme found in the nucleus. This leads to increased formation of ribosomal RNA, and therefore to stimulate the synthesis of structural and functional proteins (enzymes). As a result, the regenerative capacity is improved and the regeneration of liver cells is accelerated.

Pharmacokinetics.

Absorption – low and slow (half-absorption – 2.2 hours), metabolized in the liver by conjugation, half-life – 6.3 hours. Excreted mainly in bile in the form of glucuronides and sulfates. Does not accumulate in the body. Intestinal and hepatic circulation is noted.

Indication
Toxic liver damage: for maintenance treatment of patients with chronic inflammatory liver disease or liver cirrhosis.

Contraindication
Hypersensitivity to the fruits of milk thistle, to other components of the drug or to any of the excipients; acute poisoning of various etiologies.

Interaction with other medicinal products and other forms of interaction
Concomitant use of silymarin in the highest possible doses and oral contraceptives or drugs used in estrogen replacement therapy may reduce the effectiveness of the latter. Due to the suppression of the cytochrome P450 system, silymarin thereby enhances the effect of some drugs, namely: antiallergic drugs (fexofenadine); hypocholesterolemic drugs (lovastatin); anticoagulants (clopidogrel, warfarin); antipsychotic drugs (alprozolam, diazepam, lorazepam); antifungal drugs (ketoconazole); some drugs for the treatment of cancer (vinblastine).

Features of application
Treatment with the drug in liver disease will be more effective in dieting and abstinence from alcohol.

Due to the possible estrogen-like effect of silymarin in the highest possible doses, it should be used with caution in patients with hormonal disorders (endometriosis, uterine fibroids, carcinoma of the breast, ovary and uterus, prostate cancer). In these cases, consult a doctor.

If you have signs of jaundice (acquisition of skin color from light yellow to dark yellow, yellowing of the whites of the eyes), you should consult a doctor.

Use during pregnancy or breastfeeding.

There are no data on the effectiveness and safety of the drug during pregnancy or breastfeeding, so it should not be prescribed during this period.

Ability to influence the speed of reaction when driving a car or other machinery.

It was not noted. If the patient develops any vestibular disorders while taking the drug, he should refrain from driving or operating other machinery.

Method of application and dosage
Adults and children over 12 years of age should take 2 capsules 3 times a day. Capsules should be swallowed whole, not chewed, washed down with plenty of fluids. The course of treatment is determined by the doctor individually, depending on the nature and course of the disease.

Children

There are no adequate data from the use of this drug in children, so it should not be used in children under 12 years of age.