$31.70
Manufacturer: Ukraine
Levocin-H, a solution for infusions, is prescribed to adults for the treatment of infectious diseases caused by microorganisms sensitive to levofloxacin, such as: non-hospital pneumonia; complicated skin and soft tissue infections (only if it is considered ineffective or inappropriate to use other antibacterial agents that are usually prescribed for the treatment of these infections); acute pyelonephritis and complicated urinary tract infections; chronic bacterial prostatitis.
Description
Levocin-N solution Description
Levocin-N Composition
active substance: levofloxacin;
100 ml of solution contains levofloxacin 500 mg
excipients: sodium chloride, diluted hydrochloric acid or sodium hydroxide, water for injection.
Levocin-N Dosage form
Solution for infusion.
Basic physical and chemical properties: transparent solution of greenish-yellow color.
Levocin-N Pharmacotherapeutic group
Antibacterial agents of the quinolone group. Fluoroquinolones.
ATX code J01M A12.
Levocin-N Pharmacodynamics
Levofloxacin is a synthetic antibacterial drug from the group of fluoroquinolones, the S-enantiomer of the racemic mixture of the drug ofloxacin.
Mechanism of action. As an antibacterial agent from the group of fluoroquinolones, levofloxacin acts on the DNA-DNA-gyrase and topoisomerase IV complex.
Pharmacokinetics / pharmacodynamics ratio. The degree of bacterial activity of levofloxacin depends on the ratio of the maximum serum concentration (max) or the area under the pharmacokinetic curve (AUC) and the MIC (MIC).
Mechanism of resistance
Resistance to levofloxacin is acquired as a stepwise process of target site mutation in both types of topoisomerase II, DNA gyrase, and topoisomerase IV. Other mechanisms of resistance, such as barrier penetration (common with Pseudomonas) and efflux mechanisms, can also influence sensitivity to levofloxacin.
Cross-resistance has been established between levofloxacin and other fluoroquinolones.
Due to its mechanism of action, there is usually no cross-resistance between levofloxacin and other classes of antibacterial drugs.
Indications
Levocin-N, solution for infusion, is prescribed for the treatment of infectious diseases caused by microorganisms sensitive to levofloxacin, such as:
community-acquired pneumonia;
complicated infections of the skin and soft tissues (only if it is found ineffective or inappropriate to use other antibacterial agents that are usually prescribed to treat these infections);
acute pyelonephritis and complicated urinary tract infections;
chronic bacterial prostatitis.
The official guidelines for the proper use of antibacterial drugs should be considered.
Contraindications
Levocin-N, solution for infusion, is not prescribed in the following cases:
hypersensitivity to levofloxacin or to other quinolones, or to any of the drug excipients;
epilepsy;
complaints of adverse reactions from the tendons after prior use of quinolones;
children’s age (up to 18 years old);
During pregnancy and breastfeeding.
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