$24.60
Manufacturer: India
Infections caused by levofloxacin-sensitive microorganisms: non-hospital pneumonia, chronic bacterial prostatitis, complicated urinary tract infections, and acute pyelonephritis. The drug should be used only when it is considered inappropriate to use other antibacterial agents, usually recommended for the treatment of such infections: exacerbation of chronic obstructive pulmonary disease, including bronchitis; acute bacterial sinusitis; complicated skin and soft tissue infections.
Description
LEVOLET TABLETS COMPOSITION
active substance: levofloxacin
1 coated tablet contains levofloxacin 250 mg or 500 mg, or 750 mg as levofloxacin hemihydrate
Excipients: microcrystalline cellulose, corn starch, colloidal silicon dioxide, crospovidone, hypromellose, magnesium stearate, Opadry white OY58900 (hypromellose, titanium dioxide (E 171), polyethylene glycols).
LEVOLET TABLETS DOSAGE FORM
Film-coated tablets.
LEVOLET TABLETS MAIN PHYSICAL AND CHEMICAL PROPERTIES:
white capsule-like biconvex coated tablets, smooth on both sides (750 mg tablets).
LEVOLET TABLETS PHARMACOLOGICAL GROUP
Antibacterial agents of the quinolone group. Fluoroquinolones. ATX code J01M A12.
PHARMACOLOGICAL PROPERTIES
Pharmacological.
Microorganisms sensitive to the drug
Gram-positive aerobes Enterococcus faecalis, Staphylococcus aureus methi-S, Streptococci group C, G, Streptococcus agalactiae, Streptococcus pneumoniae peni I / S / R, Streptococcus pyogenes.
Anaerobes: Bacteroides fragilis, Clostridium perfringens, Peptostreptococcus.
Others: Chlamydia pneumoniae, Chlamydia psittaci, Legionella pneumophila, Mycoplasma pneumoniae, Ureaplasma, H. pylori.
Microorganisms that are not permanently sensitive to the drug
Gram-positive aerobes Staphylococcus aureus methi-R.
Gram-negative aerobes Burkholderia cepacia.
Anaerobes: Bacteroides ovatus, Bacteroides thetaiiotamicron, Bacteroides vulgaris, Clostridium difficile.
Microorganisms resistant to the drug
Gram-positive aerobes Staphylococcus aureus methi-R, Staphylococcus coagulase negative methi-S (1).
Like other fluoroquinolones, levofloxacin is inactive against spirochetes.
Pharmacokinetics.
Suction.
Orally administered levofloxacin is rapidly and almost completely absorbed. The peak plasma concentration is reached 1:00 after ingestion. Bioavailability is almost 100%. Levofloxacin is subject to linear pharmacokinetics in the range of 50 mg to 600 mg. Food intake has some effect on its absorption.
Distribution.
About 30-40% of levofloxacin binds to serum protein. The cumulative effect of levofloxacin at a dosage of 500 mg once a day has no clinical significance and can be disregarded. There is an insignificant, but supposed, its cumulation at a dosage of 500 mg 2 times a day. Stable distribution rates are achieved within 3 days.
FEATURES OF APPLICATION
Methicillin-resistant S. aureus. For methicillin S. aureus (MRSA), there is a very high likelihood of core-resistance to fluoroquinolones, including levofloxacin. Therefore, levofloxacin is not recommended for the treatment of infections known or suspected to be caused by MRSA, unless laboratory test results have confirmed that the agent is susceptible to levofloxacin.
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