$26.20
Manufacturer: Ukraine
Treatment of bacterial inflammatory processes in adults caused by bacteria sensitive to levofloxacin: pneumonia, complicated urinary tract infections (including pyelonephritis), skin and soft tissue infections, and chronic bacterial prostatitis.
Description
Levopro Composition
active substance: levofloxacin 100 ml of solution contains levofloxacin hemihydrate in terms of anhydrous 100% levofloxacin 500 mg
excipients: sodium chloride, sodium edetate, diluted hydrochloric acid, sodium hydroxide, water for injection.
Levopro Dosage form
Solution for infusion.
Basic physical and chemical properties:
clear liquid from yellow to greenish-yellow. Theoretical osmolarity – 300 mosmol / l.
Levopro Pharmacological group
Antibacterial agents of the quinolone group. ATC code J01M A12.
Pharmacological properties
Levopro Pharmacodynamics.
Levofloxacin is a synthetic antibacterial drug from the group of fluoroquinolones, the S-enantiomer of the racemic mixture of the drug ofloxacin.
Mechanism of action.
As an antibacterial drug from the group of fluoroquinolones, levofloxacin acts on the DNA-DNA gyrase complex and topoisomerase IV.
Pharmacokinetics / pharmacodynamics ratio.
The degree of bacterial activity of levofloxacin depends on the ratio of the maximum concentration in the blood serum (C max) or the area under the pharmacokinetic curve (AUC) and the MIC (inhibitory) concentration (MIC (MIC)).
The mechanism of resistance.
The main mechanism of resistance is a consequence of a mutation in the gyr-A genes. In vitro cross-resistance exists between levofloxacin and other fluoroquinolones.
Due to its mechanism of action, there is usually no cross-resistance between levofloxacin and other classes of antibacterial agents.
Limit values.
Recommended by the European Committee for Antimicrobial Susceptibility Testing (EUCAST) MIC limit values for levofloxacin, separating susceptible microorganisms from organisms intermediate sensitive (moderately resistant) and intermediate sensitive from resistant organisms, are presented in Table 1 MIC testing (mg / L).
Indications
Treatment in adults of bacterial inflammatory processes caused by bacteria sensitive to levofloxacin: pneumonia, complicated urinary tract infections (including pyelonephritis), skin and soft tissue infections, chronic bacterial prostatitis.
Contraindications
Hypersensitivity to levofloxacin or other quinolones, epilepsy, tendon side effects after prior use of quinolones.
Children’s age (up to 18 years old). During pregnancy and breastfeeding.
Interaction with other medicinal products and other types of interactions
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