Lexin 500 capsules №20

Description

Lexin  Storage
active substance: cephalexin;

1 capsule contains cephalexin (in the form of monohydrate) 500 mg;

Excipients: colloidal silicon dioxide, magnesium stearate, sodium starch glycolate.

Lexin  Dosage form
Capsules.

Main physical and chemical properties: capsules of size “0”, with an opaque gray lid and an orange body, with the inscription “H806” on the lid and body, contain granules of almost white color. The contents of the capsules may be in the form of a compressed mass depending on the parameters of the filling process. The quality of the drug is not affected by whether the contents of the capsules are granules or compressed mass.

Lexin  Pharmacotherapeutic group
Antibacterial agents for systemic use.

Beta-lactam antibiotics. Cephalosporins of the first generation. Cephalexin.

ATX code J01D B01.

Lexin  Pharmacological properties
Pharmacodynamics.

Cephalexin is a semi-synthetic cephalosporin antibiotic with a broad spectrum of action. Gram-positive microorganisms are sensitive to cephalexin: staphylococci (coagulase-positive and penicillinase-producing strains), streptococci (except enterococci), pneumococci. Lexin® 500 also acts on Escherichia coli, Klebsiella spp., Proteus mirabilis, Haemophilus influenza and Moraxella catarrhalis.

Pharmacokinetics.

Cefalexin is rapidly and almost completely absorbed after oral administration. The level and rate of absorption of cephalexin are almost independent of food intake. Peak serum concentrations are reached 60 minutes after drug administration. Cefalexin penetrates well into body tissues and fluids, including pericardial and pleural membranes. Only 10-15% of the active substance is bound to plasma proteins. Cefalexin is excreted mainly in the urine unchanged, and can also be excreted by hemodialysis and peritoneal dialysis.

Indication
Treatment of infections caused by cephalexin-sensitive microorganisms:

ENT organs and respiratory tract (pharyngitis, otitis media, sinusitis, sore throat, bronchitis, pneumonia);
urogenital system (pyelonephritis, cystitis, urethritis, prostatitis, epididymitis, endometritis, vulvovaginitis);
skin and soft tissues (furunculosis, abscess, phlegmon, pyoderma, lymphadenitis);
bone tissue and joints (osteomyelitis).

Contraindication
Hypersensitivity to cephalosporins or other beta-lactam antibiotics, as well as to excipients; porphyria; brain or spinal cord infections; initial therapy of severe generalized infections, the treatment of which requires the use of parenteral forms of cephalosporins.

Interaction with other medicinal products and other forms of interaction
Due to the bactericidal action of cephalexin, it should not be combined with bacteriostatic antibiotics, such as tetracyclines and chloramphenicol.

When combined with highly active diuretics (ethacrynic acid, furosemide) or potentially nephrotoxic drugs (aminoglycosides, polymyxin, colistin, amphotericin, capreomycin, vancomycin), cephalosporins may increase nephrotoxicity.

With the combined use of cephalosporins with oral anticoagulants, the prothrombin time may increase.

Concomitant use with probenecid may lead to an increase in the half-life and plasma concentrations of cephalexin.

Cephalosporins may reduce the effectiveness of oral contraceptives, so the use of additional contraceptives is recommended.

The interaction of cephalexin and metformin may lead to the accumulation of metformin.

In laboratory diagnosis, it should be borne in mind that cephalexin may cause a false-positive urine test for sugar and a positive Coombs’ reaction. False results were also observed in neonates whose mothers used cephalexin during pregnancy. Methods based on glucose oxidation reactions should be used when performing tests during the use of the drug.

Cephalosporins can affect the results of urine tests for the presence of ketone bodies.

Features of application
Before starting therapy, a history of hypersensitivity reactions to cephalosporins, penicillins or other allergens should be determined and a susceptibility test performed in advance. There may be cross-sensitivity between penicillins and cephalosporins (5-10%).

Lexin® 500 should be used with caution in patients with a predisposition to allergic diseases (hay fever, allergic dermatitis) and / or bronchial asthma.

Prolonged use of cephalexin can lead to the growth of insensitive flora and superinfection (candidiasis).

Appropriate measures should be taken in the event of a secondary infection.

Peripheral blood cell composition, liver and kidney function should be monitored regularly during treatment.

In the event of severe diarrhea characteristic of pseudomembranous colitis, it is recommended to discontinue the drug and take appropriate measures. Contraindicated use of drugs that suppress peristalsis.

Treatment with cephalosporins (including cephalexin) may be associated with decreased prothrombin activity, so n