Description

Linparza Hard Capsules 50 mg. №448 Vial

Ingredients

Each hard capsule contains 50 mg of the active ingredient Olaparib. Other ingredients include lactose monohydrate, microcrystalline cellulose, sodium starch glycolate, and magnesium stearate.

Dosage

The recommended dosage of Linparza hard capsules is 400 mg (eight capsules) taken twice daily. Dosage may vary based on individual patient characteristics, so it is essential to follow the prescribing physician’s instructions.

Indications

Linparza hard capsules are indicated for the maintenance treatment of adult patients with recurrent ovarian cancer. It is specifically used in patients who have responded to platinum-based chemotherapy.

Contraindications

Linparza hard capsules are contraindicated in patients with a known hypersensitivity to Olaparib or any of the other ingredients in the formulation. It is also not recommended for use in patients with severe hepatic impairment.

Directions

The capsules should be swallowed whole with water and can be taken with or without food. It is important not to crush or chew the capsules. If a dose is missed, patients should not take an extra dose but continue with the next scheduled dose.

Scientific Evidence

Olaparib, the active ingredient in Linparza, is a poly (ADP-ribose) polymerase (PARP) inhibitor that has shown significant efficacy in the treatment of ovarian cancer. Clinical trials have demonstrated that Olaparib maintenance therapy prolongs progression-free survival in patients with recurrent ovarian cancer compared to a placebo.

Research published in the New England Journal of Medicine has highlighted the benefits of Olaparib in patients with BRCA-mutated ovarian cancer, showing improved response rates and overall survival compared to standard chemotherapy regimens.

Additional Information

It is important for patients to inform their healthcare provider about all medications, supplements, and medical conditions before starting Linparza treatment. Regular monitoring and blood tests may be required during therapy to assess treatment response and manage any potential side effects.

Patients should be aware of potential side effects such as nausea, fatigue, and anemia while taking Linparza. It is crucial to report any unusual symptoms or side effects to a healthcare provider promptly.