$6.00
Indications:
- with essential hypertension;
- with heart failure (for symptomatic treatment);
- in acute myocardial infarction for short-term treatment of patients with stable hemodynamic parameters (no later than one day after acute infarction);
- for the treatment of initial nephropathy in patients with type II diabetes mellitus with arterial hypertension.
Description
Lipril 5 composition
active substance: lisinopril;
1 tablet contains lisinopril (in terms of 100% anhydrous lisinopril) – 5.0 mg, which corresponds to lisinopril dihydrate – 5.44 mg;
excipients: mannitol (E 421), calcium hydrogen phosphate dihydrate, corn starch, magnesium stearate.
Dosage form
Tablets.
Pharmacological properties
Lipril 5 is an antihypertensive (blood pressure lowering) drug that works by inhibiting the renin-angiotensin-aldosterone system. Suppresses the influence of the angiotensin-converting enzyme, which catalyzes the conversion of angiotensin-I into the vasoconstrictor peptide angiotensin-II, preventing its stimulating effect on the secretion of aldosterone by the adrenal glands.
Indications:
- with essential hypertension;
- with heart failure (for symptomatic treatment);
- in acute myocardial infarction for short-term treatment of patients with stable hemodynamic parameters (no later than one day after acute infarction);
- for the treatment of initial nephropathy in patients with type II diabetes mellitus with arterial hypertension.
Contraindications
You can not appoint Lipril 5:
- during pregnancy;
- with angioedema after taking such drugs (ACE inhibitors);
- during childhood;
- in case of allergy to the active substance (lisinopril), its analogues;
- with hereditary, idiopathic angioedema;
- with intolerance to the components of the tablet.
Children
The efficacy and safety of lisinopril use in children has not been established, therefore, the drug should not be used in this age category.
Application during pregnancy and lactation
Contraindicated.
Method of administration and dosage
The tablet should be taken 1 time / day in the morning, regardless of the meal, preferably at the same time.
- With arterial hypertension, 5 mg x1 times / day are prescribed. In the absence of a therapeutic effect, the dose is increased every 2–3 days by 5 mg until an average therapeutic dose of 20–40 mg / day is reached (an increase in the dose over 40 mg / day usually does not lead to a further decrease in blood pressure). The maximum dose is 40 mg per day.
- With renovascular (with narrowing of the renal artery) arterial hypertension, the drug is prescribed at an initial dose of 2.5–5 mg / day (under the control of renal function, blood pressure, and potassium levels in the blood.
If the use of the drug at the maximum dose does not cause a sufficient therapeutic effect, additional use of another antihypertensive agent is possible.
In patients receiving diuretics (diuretics), they must be canceled three days before starting Lipril. If it is impossible to cancel diuretics, an initial dose of no more than 5 mg / day is used. In this case, after taking the first dose, medical supervision is recommended for several hours, since hypotension may develop.
Overdose
Overdose symptoms: possible development of arterial hypotension (pressure drop).
Overdose treatment: it is recommended to put the patient in bed with raised legs and to carry out symptomatic treatment, including restoration of water and electrolyte balance, compensating the volume of circulating blood.
Side effects:
- Neurological disorders: mood swings, dizziness, confusion, headache.
- Digestive disorders: lack of appetite, diarrhea (loose stools), nausea, dry mouth, hepatitis, impaired taste (dysgeusia), pancreatitis, jaundice, increased activity of liver transaminases.
- Cardiovascular disorders: chest pain, rapid heartbeat (tachycardia), heart rhythm disturbances, hypotension (including orthostatic).
- Genitourinary disorders: impaired renal function (uremia, oliguria / anuria, acute failure), impotence.
- Violation of hematopoiesis: thrombocytopenia, agranulocytosis, neutropenia, decreased hematocrit, hemoglobin levels.
- Respiratory disorders: dry cough, shortness of breath, glossitis, bronchitis, sinusitis.
- Allergic reactions: angioedema, rash.
- Changes in laboratory parameters: loss of potassium (hyperkalemia), increased levels of urea nitrogen, creatinine in the blood (especially in the presence of diabetes mellitus, renal pathology, renovascular hypertension).
- Others: weakness, joint pain.
Storage conditions and periods
This medicine must be stored at a temperature of 15-25 ° C. The shelf life of this medicine is three years.
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