Livagyn-M (ketoconazole) pessaries 400 mg. №10

Description

Livagyn-M composition
active substance: ketoconazole;
1 pessary contains ketoconazole 400 mg;
excipients: butylhydroxyanisole, macrogol 1500, macrogol 400.

Dosage form
Pessaries.

Pharmacological properties
Livagyn-M belongs to antifungal drugs used topically in gynecological practice.
Ketoconazole produces a fungicidal and fungistatic effect against dermatophyte fungi, yeast (candida, cryptococci, others), higher fungi – eumycetes, as well as staphylococci and streptococci.
Fungi of the genus Aspergillus, other various fungi of the genus fucomycetes, except for the fungi entomophtralis, are less sensitive to the effects of ketoconazole.
Ketoconazole has the ability to disrupt the integrity of fungal cells by damaging their membranes. Produces inhibition of orgosterols with lanosterol.
Like other azole compounds, the antifungal effect of ketoconazole is due to its ability to inhibit cell respiration, disrupt triglyceride biosynthesis, or otherwise disrupt the cellular metabolism of fungi.
If this substance is used in high concentrations, especially with a direct physicochemical effect on fungal membranes, then the drug also has a fungicidal effect.
However, there were no cases of development of secondary resistance to ketoconazole.

Indications
Livagyn-M  is intended for topical use in the treatment of infections caused by dermatophyte and / or yeast-like fungi. Effective for fungal infections resistant to fluconazole, intraconazole, terbinafine or in patients with allergies to these drugs.
In particular, it is effective in the treatment of acute and chronic mycosis of the vagina.
Also, the drug is used to prevent fungal infections of the vagina with reduced body resistance and against the background of treatment with antibacterial agents and other drugs that disrupt the normal microflora of the vagina.

Contraindications
The drug in question is not used if the patient has ever had hypersensitivity (allergy) to one of the components that make up its composition.
Also contraindicated for:

• acute or chronic liver disease;
• concomitant use of HMG-GoA inhibitor drugs – terfenadine, astemizole, sertindole, cisapride, quinidine, pimozide, bepridil, halofantrine, disopyramide, dofetilide, midazolam, lovastatin, and others.

Children
The drug is not used in children.

Application during pregnancy and lactation
This drug is used with caution to treat pregnant women and women who are currently breastfeeding mothers.
It is strictly contraindicated to use in the first trimester of pregnancy.

Method of administration and dosage
Treatment begins only after an analysis of the sensitivity and type of fungus.
When used for treatment, it is necessary to inject 1 suppository 1 time per day, before going to bed.
The introduction of the suppository is made in the supine position.
The duration of treatment is 3 to 5 days. In the chronic form of the disease – 10 days
Treatment can be considered complete after laboratory confirmation.
Before use, you should wash your hands thoroughly and avoid contact of the suppository with latex products, including condoms.

Overdose
An overdose of this drug can theoretically cause an increase in the side effects described below.
At the same time, at the moment, no cases of overdose have been recorded.

Side effects
The use of this drug in a patient can cause side effects in the form of:

• itching, burning at the injection site;
• discomfort in the vagina.

There were cases of dizziness, nausea.
Usually side effects are transient and rarely require intervention, passing along with drug withdrawal (except for liver complications).

Storage conditions and periods
The shelf life is up to 2 years.
Storage Livagyn-M temperature should not exceed 25 ° C.