Locren (betaxolol) coated tablets 20 mg. №28

Description

Locren composition
active substance: betaxolol;
1 tablet contains betaxolol hydrochloride 20 mg;
excipients: lactose monohydrate, microcrystalline cellulose, sodium starch glycolate (type A), colloidal anhydrous silica, magnesium stearate;
shell: hypromellose, titanium dioxide (E 171), polyethylene glycol.

Dosage form
Coated tablets.

Pharmacological properties
Locren is a medicine used for cardiac diseases. The drug causes a decrease in the heart rate at rest or during exercise (due to internal sympathomimetic activity, blockade of beta-adrenergic receptors), reduces cardiac output (due to competitive antagonism with catecholamines), reduces diastolic and systolic blood pressure, reduces the reflex of orthostatic tachycardia.

Indications
Locren is prescribed for the treatment of arterial hypertension, prevention of bouts of angina pectoris.

Contraindications
You cannot appoint Locren:

• if you are allergic to betaxolol, intolerance to the components;
• with acute heart failure;
• with decompensation of chronic heart failure;
• with cardiogenic shock;
• with severe bronchial asthma, COPD;
• with atrioventricular block II and III degree (without an artificial pacemaker);
• with Prinzmetal’s angina;
• with bradycardia (heart rate less than 45-50 beats / minute);
• with a severe form of Raynaud’s disease, obliterating arterial disease;
• with sick sinus syndrome (including SA blockade);
• with pheochromocytoma;
• with arterial hypotension;
• with anaphylactic reactions in the past;
• with simultaneous use with sultopride, floctaphenin, monoamine oxidase inhibitors;
• with metabolic acidosis;
• with cardiomegaly;
• under 18 years old.

Use with caution:

• with psoriasis;
• with bronchial asthma, COPD mild / moderate course;
• with compensated chronic heart failure;
• with AV blockade of the 1st degree;
• with treated pheochromocytoma;
• with old age;
• with renal / hepatic impairment;
• with diabetes mellitus;
• with obliterating diseases of the peripheral arteries;
• when carrying out desensitizing therapy.

Children
Safety and effectiveness of the drug in children have not been established, so its use in this category of patients is contraindicated.

Application during pregnancy and lactation
Not recommended.
Effect on the fetus: bradycardia, hypoglycemia, growth retardation.

Method of administration and dosage
Locren tablet is taken orally whole and washed down with a sufficient amount of water.
The initial is usually 10 mg. If within 1–2 weeks of treatment the target values ​​of blood pressure are not achieved, then the dose is doubled to 20 mg per day. The maximum dose that can be taken per day is 40 mg.

Overdose
Overdose symptoms: severe bradycardia, AV block, dizziness, drop in blood pressure, arrhythmias, ventricular premature beats, fainting, heart failure, difficulty breathing, convulsions, cyanosis of fingernails and palms.
Overdose treatment: washing the stomach, taking adsorbents, symptomatic treatment.

Side effects
Various skin reactions are possible (rash, psoriasis-like rashes, itching, urticaria, exacerbation of psoriasis), dizziness, paresthesia, headache, confusion, dry eyes, depression, asthenia, visual disturbances, mental disorders, insomnia, hallucinations, nightmares, gastralgia, nausea, changes in stool, increase / decrease in glucose levels, bradycardia, development / worsening of heart failure (swelling of the legs, feet, legs), drop in blood pressure, AV block, decreased skin temperature of the upper / lower extremities, manifestations of angiospasm, increased frequency of angina attacks, bronchospasm , impotence, changes in laboratory tests (appearance of antinuclear antibodies), decreased intraocular pressure, withdrawal syndrome.

Storage conditions and periods
At 15-25 ° С. Locren’s shelf life is 5 years.