Loraxon (ceftriaxone) powder 1000 mg. №12 vial

$97.20

Loraxon is used for the treatment of infections, causative agents of which show sensitivity to ceftriaxone. In particular, for the treatment of infections:

  • Respiratory tract, including inflammation of the lungs, throat, nose, including pneumonia, COPD;
  • Ears (otitis media in acute form);
  • organs of the abdominal cavity;
  • Kidneys and urinary tract;
  • Genital organs, including gonorrhea, syphilis;
  • soft tissue bones, wound infections;
  • in immunocompromised patients;
  • In meningitis, sepsis, disseminated Lyme borreliosis. It is used as preoperative prophylaxis of infections during surgical intervention.
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Description

Loraxon composition
active substance: ceftriaxone;
1 vial contains ceftriaxone sodium in an amount corresponding to ceftriaxone 1000 mg.

Dosage form
Powder for solution for injection.

Pharmacological properties
Loraxon is an antibacterial medicine for systemic use, the main active ingredient is sodium ceftriaxone. It belongs to the group of beta-lactam antibiotics, being a III generation cephalosporin. It has prolonged action, it is used exclusively parenterally (bypassing the gastrointestinal tract).

Indications
Loraxon is used for the treatment of infections, causative agents of which show sensitivity to ceftriaxone. In particular, for the treatment of infections:

  • Respiratory tract, including inflammation of the lungs, throat, nose, including pneumonia, COPD;
  • Ears (otitis media in acute form);
  • organs of the abdominal cavity;
  • Kidneys and urinary tract;
  • Genital organs, including gonorrhea, syphilis;
  • soft tissue bones, wound infections;
  • in immunocompromised patients;
  • In meningitis, sepsis, disseminated Lyme borreliosis. It is used as preoperative prophylaxis of infections during surgical intervention.

When prescribing ceftriaxone, official recommendations for prevention of antibiotic resistance should be followed.
Mycoplasma, mycobacteria and chlamydia are resistant to cephalosporins.
The active substance of the drug – ceftriaxone – is a parenteral cephalosporin antibiotic of III generation, which has prolonged action.
Bactericidal activity of this drug is due to its ability to inhibit the synthesis of cell membranes, which leads to lysis of the bacterial cell and its death. It shows activity against most gramnegative and gram-positive microorganisms.
In addition, ceftriaxone is characterized by high resistance to most beta-lactamases.

Contraindications
It is not used if the patient is allergic to cephalosporins or the drug used to prepare the solution. If the patient has an allergy to penicillins, the possibility of a cross-reaction of hypersensitivity to ceftriaxone should be considered.
It is also not used for the treatment of premature infants (up to 41 weeks), as well as for hyperbilirubinemia in newborns and premature infants.
Incompatible with amsacrine, vancomycin, fluconazole and aminoglycosides.
Contraindicated in the presence of jaundice and acidosis.
The use of this drug in combination with calcium-containing solutions is categorically contraindicated. It is also prohibited to use solutions containing calcium for 48 hours after administration of ceftriaxone because of the high risk of formation of precipitates of calcium salt of ceftriaxone.

Children
The drug should be used in children from birth.

Use in pregnancy and lactation
There are no data on its safety during pregnancy, so it is permissible to prescribe, particularly in the first trimester, only if the risks from its use are lower than the expected benefits.
Ceftriaxone tends to penetrate the placenta, so breastfeeding should be suspended if its use is necessary.

Dosage and administration method
Loraxon is applied parenterally, as intramuscular, intravenous injections or infusions. Do not mix in one syringe/flask with other drugs.
The average dosage for adults and children over 12 years of age is 1-2 grams of ceftriaxone. It is usually administered once a day. The maximum daily dose is 4 grams.
In severe infections or in case of weak sensitivity to ceftriaxone the daily dose may be increased to 2-4 grams (in neutropenia with fever, in case of bacterial infection, bacterial endocarditis or meningitis). Treatment duration ranges from 1 day for gonorrhea to 21 days for aggravated infections (particularly disseminated Lyme borreliosis). The exact dosage, route of administration and duration of treatment is determined by the doctor, depending on the severity of the disease and the characteristics of the patient’s body.
Preparation of injection for intramuscular injection: dissolve 1 g of ceftriaxone in 3.5 ml of lidocaine solution (1%).
Preparation of intravenous injection: Dissolve 1 gram of the drug in 10 ml of water for injection. Injection is slow, within 4-5 minutes.
Preparation of solution for intravenous drip infusion: dissolve 2 grams of Loraxon in 40 ml of one of the drugs:

  • 0.9% sodium chloride;
  • 0.45% sodium chloride + 2.5% glucose;
  • 5% glucose;
  • 10% glucose;
  • 6% dextran in 5% glucose solution;
  • 10% hydroxyethylated starch.

When prescribed for the treatment of children, the recommended dosage is:

  • newborns up to 2 weeks – at the rate of 20 to 50 mg per 1 kg of weight (infusion lasts at least 60 minutes);
  • children from 15 days to 12 years old – at the rate of 20 to 80 mg per 1 kg of weight.

In severe cases 80 mg per 1 kg of weight is prescribed. Children with a weight of more than 50 kg receive the dosage at the rate of an adult patient.
Doses of 50 mg per 1 kg and above are administered for at least 30 minutes. The maximum dosage is 80 mg per 1 kg of patient weight. The only exception is the treatment of meningitis in children under 12 years of age, when a dosage of 100 mg per 1 kg of weight is prescribed.
Elderly patients, as well as in case of renal and hepatic disorders, dosage adjustment is not required, if their functions remain normal.

Overdose
Overdose may cause nausea, vomiting, diarrhea (diarrhea). Symptomatic treatment is prescribed.
Hemodialysis is ineffective. The antidote is unknown.

Side effects
Patients usually tolerate the use of ceftriaxone well. However, reactions such as:

  • fungal infections;
  • eosinophilia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia, prothrombin time may increase;
  • diarrhea, nausea, vomiting, stomatitis, pancreatitis, bile stasis;
  • Precipitates of calcium salt of ceftriaxone in gallbladder;
  • rash, itching, urticaria, edema;
  • oliguria, hematuria, formation of kidney stones;
  • headache, fever, anaphylaxis reactions.

In rare cases, inflammation of the walls of the veins has been observed, so the drug is administered slowly. For pain relief, dilution with lidocaine is recommended (only for intramuscular administration).

Conditions and terms of storage
Store for 3 years at a temperature not exceeding 30 ° C.