Lospirin (acetylsalicylic acid) tablets 75 mg. №120

Description

Lospirin tablets 75 mg composition
Active substance:
acetylsalicylic acid (acetylsalicylic acid) – 75 mg;
excipients: microcrystalline cellulose, corn starch, anhydrous colloidal silicon dioxide, stearic acid, Opadry Y-1-7000 white, Acryl-Eze 93О18359 white.

Dosage form
Enteric-coated tablets.

Pharmacological properties
Acetylsalicylic acid inhibits platelet aggregation by blocking the synthesis of thromboxane A2. The mechanism of its action is the irreversible inactivation of the enzyme cyclooxygenase (COX-1). This inhibitory effect is especially pronounced for platelets, since they are not capable of resynthesis of the specified enzyme.
Acetylsalicylic acid has other inhibitory effects on platelets. Due to the indicated effects, it can be used for many vascular diseases.
Acetylsalicylic acid belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) with analgesic, antipyretic and anti-inflammatory properties.
Oral acetylsalicylic acid in higher doses can be used to relieve pain and in mild febrile conditions such as colds and flu, to reduce fever and relieve joint and muscle pain, in acute and chronic inflammatory diseases such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.

Indications
Lospirin is prescribed:

• to reduce the risk of secondary dissection of coronary arteries, restenosis after stent placement, balloon coronary angioplasty;
• with ischemic heart disease or the presence of several risk factors for its development;
• with unstable angina pectoris;
• with a painless form of myocardial ischemia (for the prevention of myocardial infarction);
• for the prevention of ischemic stroke in individuals with ischemic stroke, transient ischemic attack in the past;
• for the prevention of repeated myocardial infarction in persons with a heart attack in the past;
• for the prevention of thromboembolism in coronary artery vasculitis (Takayasu’s aortoarteritis, Kawasaki disease), valvular mitral heart disease, atrial fibrillation, mitral valve prolapse;
• with mild / moderate pain syndrome (migraine, osteoarthritis, painful menstruation, headache, arthritis pain, toothache);
• with rheumatoid arthritis, rheumatic fever, pericarditis, Dressler’s syndrome, rheumatic chorea;
• with diseases of the spine, accompanied by pain (sciatica, lumbago);
• with neuralgia, myalgia.

Contraindications:

• with a deficiency of the enzyme glucose-6-phosphate dehydrogenase;
• with erosive / ulcerative lesions of the stomach or intestines in the acute phase;
• if you are allergic to acetylsalicylic / salicylic acid;
• with portal hypertension;
• with “aspirin” asthma, “aspirin” triad;
• with gastrointestinal bleeding;
• with hemorrhagic diathesis (thrombocytopenic purpura, von Willebrand disease, telangiectasias), hemophilia, hypoprothrombinemia;
• with dissecting aortic aneurysm;
• with a deficiency of vitamin K;
• when taking methotrexate at a dose of ≥15 mg / week;
• with kidney / liver failure;
• during pregnancy (I and III trimester), breastfeeding;
• with gout, gouty arthritis.

Children
Do not administer the drug to children.
The use of acetylsalicylic acid in children under the age of 18 can cause serious side effects (including Reye’s syndrome, one of the signs of which is constant vomiting).

Application during pregnancy and lactation
In the I and III trimesters, taking this medication is contraindicated. In the II trimester, occasional use is allowed.
The components of the drug can penetrate into breast milk, therefore, if treatment is necessary, the child should be weaned.

Method of administration and dosage
Lospirin tablets is administered orally, preferably between meals.

• In case of myocardial infarction, as well as for secondary prophylaxis in persons who have suffered a heart attack – 40–325 mg / day, in the evening.
• To reduce platelet aggregation, prevent thromboembolic complications – 250–325 mg / day for an extended period.
• For ischemic attacks, cerebral thromboembolic complications – 250–325 mg / day with a gradual increase to 1000 mg / day.
• For the prevention of thrombosis, occlusion of the aortic shunt – 325 mg every 7 hours through a nasogastric tube, then in the same dose inside x3 times / day in combination with dipyridamole.

Overdose
Overdose symptoms: ringing in the ears, hyperventilation (due to stimulation of the respiratory center), alkalosis or metabolic acidosis, severe shortness of breath, fever, collapse, coma, hypoprothrombinemia, convulsions, respiratory and renal failure.
Relief measures include gastric lavage (or provocation of vomiting), discontinuation of medication, intake of enterosorbent, saline laxatives, introduction of alkalizing agents, restoration of BCC, forced alkaline diuresis (infusion of sodium bicarbonate, 5% glucose, furosemide), correction of acid base balance, if necessary – hemodialysis, mechanical ventilation.

Side effects
Possible erosive and ulcerative lesions of the stomach / intestines, nausea, stomach pain, loss of appetite, gastrointestinal bleeding, liver failure, allergic reactions (skin rash, “aspirin” asthma, angioedema), the development of interstitial nephritis, nephrotic syndrome, papillary necrosis , renal failure (when used for a long time), Reye’s syndrome, heart failure, neurological disorders (tinnitus, dizziness, visual impairment, headache, aseptic meningitis, hearing loss), the development of addiction after drug withdrawal. There may also be changes in the blood test: thrombocytopenia, anemia (anemia), leukopenia.

Storage conditions and periods
At 15-25 ° С. The shelf life of the Lospirin tablets is 4 years.